Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

13.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.2K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

472
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
472
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

367
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
367
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

229
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
229
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

717
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
717
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

169
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
169

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Open versus laparoscopic inguinal hernia repair in patients with obesity: a NSQIP propensity-matched analysis of 59,943 elective, emergency, and recurrent cases.

Hernia : the journal of hernias and abdominal wall surgery·2026
Same author

High Negative Predictive Value but Moderate Overall Performance of Synovasure Compared With Joint Aspirate Culture in the Diagnosis of Prosthetic Joint Infection.

Cureus·2026
Same author

Sertraline to reduce recidivism in impulsive violent offenders (ReINVEST): a randomised double blind clinical trial.

EClinicalMedicine·2025
Same author

Long-term outcomes of single-stage versus two-stage revision for prosthetic joint infection: a retrospective, observational cohort study.

Orthopedic reviews·2025
Same author

Addressing the unmet needs of bipolar disorder in Australia and beyond.

The Australian and New Zealand journal of psychiatry·2025
Same author

Reliability of Radiographic Union Score and correlation of clinical outcomes in children operated for supracondylar humerus fracture: A prospective study.

Journal of children's orthopaedics·2025

Related Experiment Video

Updated: Dec 27, 2025

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction
10:35

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction

Published on: December 3, 2017

11.5K

Serial C-reactive Protein Monitoring in Prosthetic Joint Infection: A Powerful Predictor or Potentially Pointless?

Rafia Ghani1, Jonathan Hutt2, Philip Mitchell2

  • 1Orthopaedics, Russells Hall Hospital, Dudley, GBR.

Cureus
|February 25, 2020
PubMed
Summary
This summary is machine-generated.

Serum C-reactive protein (CRP) monitoring is often used to track prosthetic joint infection (PJI) treatment success. However, this study found CRP levels did not reliably indicate if PJI was successfully resolved after surgery.

Keywords:
arthroplastyblood testinginfectioninflammatoryorthopaedicsprostheticprosthetic jointrevision

More Related Videos

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
04:37

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

1.2K
A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

1.7K

Related Experiment Videos

Last Updated: Dec 27, 2025

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction
10:35

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction

Published on: December 3, 2017

11.5K
Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
04:37

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

1.2K
A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

1.7K

Area of Science:

  • Orthopedic Surgery
  • Infectious Diseases
  • Biomarkers

Background:

  • Serum C-reactive protein (CRP) is a key initial diagnostic marker for prosthetic joint infection (PJI).
  • Current clinical practice often relies on CRP to assess PJI treatment resolution, but lacks robust supporting evidence.
  • Established algorithms for PJI resolution are not widely accepted.

Purpose of the Study:

  • To evaluate the efficacy of serial CRP measurements in determining prosthetic joint infection (PJI) resolution.
  • To assess the diagnostic accuracy of CRP in identifying persistent PJI after surgical intervention.

Main Methods:

  • Retrospective analysis of an arthroplasty database including 121 patients (75 hip, 48 knee) treated for PJI.
  • Comparison of pre- and postoperative CRP values for patients undergoing debridement, antibiotics, and implant retention (DAIR), single-stage revision, or two-stage revision.
  • Calculation of Receiver Operating Characteristic (ROC) curves to determine CRP's sensitivity and specificity for persistent infection.

Main Results:

  • No statistically significant difference in mean CRP values was observed between successful and unsuccessful PJI treatment groups.
  • The area under the ROC curve (AUC) for CRP predicting treatment outcomes varied between 0.46 and 0.73.
  • 26 out of 121 patients experienced persistent infection.

Conclusions:

  • Serial CRP monitoring is not supported by this study's data as a reliable indicator for successful prosthetic joint infection (PJI) eradication.
  • Further research may be needed to identify more accurate biomarkers or methods for PJI resolution assessment.