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Updated: Dec 27, 2025

Ultrasonographic Assessment During Cardiopulmonary Resuscitation
Published on: October 24, 2020
Cardiac Thrombus Formation During Cardiopulmonary Resuscitation for Cardiac Arrest: Is It Time for
Cesare de Gregorio1, Alessio Stanzione1
1Department of Clinical and Experimental Medicine, Cardiology Unit, Postgraduate Residency School on Cardiovascular Diseases, University Hospital G. Martino, Messina, Italy.
Insights
Current guidelines consider thrombosis a cause of cardiorespiratory arrest. This case study shows cardiac thrombus formation is a consequence of cardiac standstill, resolving with heparin and CPR.
Area of Science:
- Cardiology
- Critical Care Medicine
- Pathophysiology
Background:
- Current guidelines suggest thrombosis may cause cardiorespiratory arrest (CA).
- Cardiac thrombus formation (TF) is often considered a consequence, not a cause, of cardiac standstill.
- Infective endocarditis can lead to severe complications, including cardiac events.
Observation:
- A young male patient with infective endocarditis experienced sudden cardiac arrest (CA).
- During cardiopulmonary resuscitation (CPR), echocardiography revealed unexpected thrombus formation in the right atrium.
- The patient achieved return of spontaneous circulation after 16 minutes of CPR.
Findings:
- The cardiac thrombus resolved rapidly with intravenous heparin administration and continued chest compressions.
- This case challenges the traditional view of thrombosis as a primary cause of CA.
- Echocardiography played a crucial role in diagnosing and managing the cardiac thrombus during resuscitation.
Implications:
- Cardiac thrombus formation may be a consequence of circulatory arrest rather than a cause.
- Early recognition and treatment of cardiac thrombus during CPR can be life-saving.
- Cardiac ultrasound may prove valuable in managing cardiorespiratory arrest patients, despite not being routine.
Abstract:
Current guidelines consider thrombosis as a potential (and reversible) cause of cardiorespiratory arrest (CA). However, cardiac thrombus formation (TF) is likely to be the consequence of the forward blood flow ceasing during cardiac standstill. We present the case of a young man who was hospitalized for infective endocarditis, complicated by multiorgan disease and sudden CA on the 5th day. Prompt cardiopulmonary resuscitation (CPR) warranted a return of spontaneous circulation in 16 min but, unexpectedly, a TF was recognized in the right atrium at echocardiography. The blood clot resolved with rapid administration of endovenous heparin and continued chest compressions. Even though cardiac ultrasound is not ready for a routine use during CPR, the present study confirms a key role in the management of CA patients.
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