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H-Type Hypertension Is a Risk Factor for Cerebral Small-Vessel Disease

Tan Li1, Xueyun Liu1, Shanshan Diao1

  • 1Department of Neurology, The First Affiliated Hospital of Soochow University, No. 899 Pinghai Road, Suzhou, Jiangsu 215006, China.

Biomed Research International
|February 25, 2020
PubMed

Insights

H-type hypertension is linked to a greater burden of cerebral small-vessel diseases (CSVD), including microbleeds and white matter changes. Combined hypertension and hyperhomocysteinemia significantly worsen CSVD burden.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Medical Imaging

Background:

  • Cerebral small-vessel diseases (CSVD) are a significant cause of stroke and cognitive impairment.
  • The specific association between H-type hypertension and the spectrum of CSVD remains incompletely understood.

Purpose of the Study:

  • To investigate the relationship between H-type hypertension and the presence and severity of various CSVD markers.
  • To evaluate the overall burden of CSVD in patients with H-type hypertension compared to other groups.

Main Methods:

  • A cohort of 329 patients was categorized into four groups: H-type hypertension, isolated hypertension, isolated hyperhomocysteinemia (HHcy), and controls.
  • Cerebral small-vessel disease features were assessed using MRI, and a total CSVD burden score was calculated.
  • Clinical data, including age, blood pressure, and triglycerides, were collected.

Main Results:

  • H-type hypertension correlated with cerebral microbleeds (CMBs), white-matter hyperintensities (WMHs), and peripheral vascular space (PVS).
  • CSVD total burden was significantly associated with age, systolic pressure, triglycerides, isolated HHcy, and H-type hypertension.
  • A synergistic effect was observed between hypertension and HHcy on the total CSVD burden.

Conclusions:

  • H-type hypertension is independently associated with the CSVD spectrum and overall burden, highlighting the need for targeted prevention.
  • The combined presence of hypertension and HHcy significantly exacerbates CSVD, suggesting a critical interaction for clinical consideration.
Abstract

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