Related Experiment Video

Updated: Dec 27, 2025

Assessing Murine Resistance Artery Function Using Pressure Myography
07:25

Assessing Murine Resistance Artery Function Using Pressure Myography

Published on: June 7, 2013

22.9K

Genetic Background of Hypertension in Connective Tissue Diseases

Bogna Grygiel-Górniak1, Iwona Ziółkowska-Suchanek2, Elżbieta Kaczmarek3

  • 1Department of Rheumatology and Internal Diseases, Poznan University of Medical Sciences, Poznan 61-545, Poland.

Journal of Immunology Research
|February 25, 2020
PubMed

Insights

Connective tissue diseases (CTD) and specific gene variations like PPAR gamma-2 and ADRB3 influence hypertension risk. These genetic factors, along with age and body fat, predict hypertension and metabolic complications in CTD patients.

Area of Science:

  • Genetics and Molecular Biology
  • Cardiovascular Disease Research
  • Metabolic Syndrome Studies

Background:

  • Peroxisome proliferator-activated receptors (PPAR gamma-2) and beta-3-adrenergic receptors (ADRB3) are implicated in hypertension risk.
  • The specific roles of PPAR gamma-2 and ADRB3 in blood pressure regulation within connective tissue diseases (CTD) remain unclear.

Purpose of the Study:

  • To investigate the association between PPAR gamma-2 and ADRB3 gene polymorphisms and hypertension in patients with CTD.
  • To identify genetic and clinical predictors of hypertension and associated metabolic complications in CTD.

Main Methods:

  • Genotyping of 104 CTD patients and 103 controls for PPAR gamma-2 (Pro12Ala, C1431T) and ADRB3 (Trp64Arg) polymorphisms.
  • Analysis of anthropometric, biochemical data, and blood pressure measurements.
  • Utilized TaqMan® SNP genotyping assays and PCR-RFLP for genotyping.

Main Results:

  • No significant difference in genotype/allele prevalence between CTD patients and controls, or between hypertensive and normotensive subjects.
  • CTD patients exhibited lower body fat, higher body water, glucose, and triglyceride levels.
  • Hypertensive subjects were older with higher BMI, waist circumference, body water, glucose, and TG.
  • Multivariate analysis indicated that Ala12/X or Trp64Trp genotypes were associated with higher body mass and WC in hypertensive individuals.
  • Trp64Trp polymorphism correlated with higher TG levels, and T1431/X with higher WC.
  • CTD presence, visceral fat distribution, and age were identified as hypertension predictors.
  • Hypertensive CTD patients with Trp64Trp showed increased risk of visceral obesity and metabolic issues.
  • Ala12/X or T1431/X predicted visceral fat distribution in hypertensive subjects.

Conclusions:

  • Age, CTD, and visceral fat distribution are key predictors of hypertension.
  • Specific PPAR gamma-2 and ADRB3 polymorphisms may influence body composition and metabolic parameters, impacting hypertension risk and severity in CTD patients.
  • Trp64Trp polymorphism is linked to increased risk of visceral obesity and metabolic complications in hypertensive CTD patients.

More Related Videos

Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta08:08

Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta

Published on: June 10, 2015

11.7K
Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

4.1K

Related Concept Videos

Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
630
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.5K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
379
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
502
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
587
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
299