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Published on: April 10, 2018
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A guide to naming human non-coding RNA genes.
Ruth L Seal1,2, Ling-Ling Chen3, Sam Griffiths-Jones4
1Department of Haematology, University of Cambridge School of Clinical Medicine, Cambridge, UK.
The EMBO Journal
|February 25, 2020
Summary
Standardizing gene symbols for non-coding RNAs (ncRNAs) brings order to research. The HUGO Gene Nomenclature Committee (HGNC) assigns official names, ensuring clear communication about these crucial genetic elements.
Area of Science:
- Genetics
- Molecular Biology
- Bioinformatics
Background:
- Non-coding RNA (ncRNA) research is rapidly expanding.
- Accurate gene symbols and names are essential for clear communication in ncRNA studies.
- The HUGO Gene Nomenclature Committee (HGNC) is the authority for human gene symbol approval.
Purpose of the Study:
- To review major classes of ncRNA in the human genome.
- To describe the standardized nomenclature assignment for each ncRNA class.
- To ensure accurate and informative ncRNA gene naming.
Main Methods:
- Review of currently annotated human ncRNA classes.
- Consultation with specialist advisors for ncRNA nomenclature.
- Description of the HGNC's systematic approach to assigning gene symbols and names.
Main Results:
- Identification of major ncRNA classes requiring standardized nomenclature.
- Elucidation of the process for assigning official gene symbols and names to ncRNAs.
- Establishment of a framework for consistent ncRNA gene identification.
Conclusions:
- Standardized nomenclature for ncRNA genes is critical for advancing research.
- The HGNC provides authoritative and informative naming conventions for ncRNAs.
- Consistent naming facilitates unambiguous communication and data integration in the field.
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