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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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A guide to naming human non-coding RNA genes.

Ruth L Seal1,2, Ling-Ling Chen3, Sam Griffiths-Jones4

  • 1Department of Haematology, University of Cambridge School of Clinical Medicine, Cambridge, UK.

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|February 25, 2020
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Summary
This summary is machine-generated.

Standardizing gene symbols for non-coding RNAs (ncRNAs) brings order to research. The HUGO Gene Nomenclature Committee (HGNC) assigns official names, ensuring clear communication about these crucial genetic elements.

Keywords:
gene nomenclaturegene symbolsnon-coding RNA

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Area of Science:

  • Genetics
  • Molecular Biology
  • Bioinformatics

Background:

  • Non-coding RNA (ncRNA) research is rapidly expanding.
  • Accurate gene symbols and names are essential for clear communication in ncRNA studies.
  • The HUGO Gene Nomenclature Committee (HGNC) is the authority for human gene symbol approval.

Purpose of the Study:

  • To review major classes of ncRNA in the human genome.
  • To describe the standardized nomenclature assignment for each ncRNA class.
  • To ensure accurate and informative ncRNA gene naming.

Main Methods:

  • Review of currently annotated human ncRNA classes.
  • Consultation with specialist advisors for ncRNA nomenclature.
  • Description of the HGNC's systematic approach to assigning gene symbols and names.

Main Results:

  • Identification of major ncRNA classes requiring standardized nomenclature.
  • Elucidation of the process for assigning official gene symbols and names to ncRNAs.
  • Establishment of a framework for consistent ncRNA gene identification.

Conclusions:

  • Standardized nomenclature for ncRNA genes is critical for advancing research.
  • The HGNC provides authoritative and informative naming conventions for ncRNAs.
  • Consistent naming facilitates unambiguous communication and data integration in the field.