Related Experiment Video
Updated: Dec 27, 2025
09:43
Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair
Published on: February 24, 2016
10.4K
Autologous bionic tissue for inguinal hernia repair
Hongyi Liu1, Weibin Chen1, Bin Zhao1
1School of Medicine, Xiamen University, Xiamen, Fujian Province, People's Republic of China.
Journal of Biomedical Materials Research. Part A
|February 25, 2020
Summary
This study introduces autologous bionic tissue (ABT) for hernia repair, combining stem cells and biomaterials to improve healing. ABT enhances tissue regeneration and reduces inflammation compared to traditional meshes.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Prosthetic meshes used in hernioplasty can cause complications like chronic pain and infection due to fibrotic scarring and shrinkage.
- Current treatments lack optimal solutions for promoting natural tissue integration and reducing adverse effects.
Purpose of the Study:
- To develop and evaluate an autologous bionic tissue (ABT) for inguinal hernioplasty, aiming to improve tissue regeneration and reduce complications.
- To assess the efficacy of ABT, composed of mesenchymal stem cells (MSCs), poly (lactic-co-glycolic acid) (PLGA) scaffolds, and extracellular matrix (ECM), in promoting a favorable healing environment.
Main Methods:
- Constructing ABT by seeding autologous bone marrow-derived MSCs onto PLGA porous scaffolds and allowing ECM production.
- Characterizing ECM composition and degradation kinetics, including structural proteins, macromolecules, and cytokines (MMP-9, TIMP-1).
- Evaluating ABT's in vitro and in vivo performance, comparing it with PLGA scaffolds, focusing on inflammatory response, vascularization, mechanical properties, and tissue regeneration.
Main Results:
- ABT demonstrated enhanced mechanical properties, elasticity, and flexibility due to ECM integration.
- In vivo studies showed ABT significantly inhibited inflammatory factors and promoted anti-inflammatory responses, reducing the M1/M2 macrophage ratio.
- ABT implantation resulted in increased tissue regeneration thickness, vascularization, and superior mechanical properties compared to PLGA alone.
Conclusions:
- Autologous bionic tissue (ABT) effectively promotes tissue regeneration in hernia repairs by mitigating PLGA-induced inflammation and enhancing host cellular infiltration.
- The combination of MSCs and ECM in ABT offers a promising alternative to conventional prosthetic meshes, improving healing outcomes and reducing patient discomfort.
- ABT's ability to modulate the inflammatory environment and support vascularization underscores its potential for advanced reconstructive surgery.
