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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
Coronavirus disease 2019: Implications of emerging infections for transplantation
Marian G Michaels1, Ricardo M La Hoz2, Lara Danziger-Isakov3
1Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Abstract:
The recent identification of an outbreak of 2019- novel Coronavirus is currently evolving, and the impact on transplantation is unknown. However, it is imperative that we anticipate the potential impact on the transplant community in order to avert severe consequences of this infection on both the transplant community and contacts of transplant patients.
Insights
The 2019 novel Coronavirus outbreak
Area of Science:
- Transplantation and infectious diseases
Background:
- An outbreak of 2019 novel Coronavirus (2019-nCoV) has been identified.
- The impact of this emerging virus on organ transplantation is currently unknown.
Purpose of the Study:
- To anticipate the potential impact of 2019-nCoV on the transplant community.
- To prepare for and mitigate severe consequences of the infection.
Main Methods:
- This is a perspective/opinion piece based on current knowledge.
- Anticipatory strategies are discussed.
Main Results:
- The full impact of 2019-nCoV on transplantation is yet to be determined.
- Proactive planning is essential.
Conclusions:
- The transplant community must prepare for the evolving 2019-nCoV outbreak.
- Mitigating the infection's effects on patients and their contacts is crucial.
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