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Cangrelor use in a 6-year-old patient undergoing complex percutaneous coronary intervention after post-surgical

Domenico Sirico1, Nuccia Morici1, Francesco Soriano1

  • 1'De Gasperis' Cardio Center, Niguarda Hospital , Milan, Italy.

Platelets
|February 25, 2020
PubMed

Insights

Cangrelor effectively treated acute myocardial infarction in a pediatric patient with coronary artery anomaly after surgery. This intravenous P2Y12 inhibitor allowed controlled platelet inhibition during urgent percutaneous coronary intervention.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Interventional Cardiology

Background:

  • Cangrelor, an intravenous P2Y12 receptor antagonist, is approved for adults undergoing percutaneous coronary intervention.
  • Its pharmacokinetics enable controllable peri-procedural platelet inhibition.

Observation:

  • A 6-year-old child with anomalous right coronary artery origin underwent surgical conduit replacement.
  • The surgery resulted in acute myocardial infarction due to extrinsic coronary compression.

Findings:

  • Urgent percutaneous coronary intervention with simultaneous V-stenting was performed.
  • The patient received cangrelor infusion, followed by a switch to clopidogrel therapy.
  • This treatment successfully managed the acute myocardial infarction.

Implications:

  • This case demonstrates the successful use of cangrelor in a pediatric patient for peri-procedural platelet inhibition during urgent PCI.
  • It highlights cangrelor as a viable option for managing acute coronary events in children with complex congenital heart defects.
  • Further research into pediatric cangrelor use is warranted.

Keywords:
CangrelorPCIcongenital heart diseasecoronary compressionmyocardial infarction

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