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Related Experiment Videos

Acquired peripapillary changes and progression in glaucoma.

E J Rockwood1, D R Anderson

  • 1Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, FL 33101.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|January 1, 1988
PubMed
Summary
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Retinal pigment epithelium (RPE) changes near the optic disc occur naturally over time but are also seen in glaucoma. These RPE alterations in glaucoma are generally too small to explain common optic disc features.

Area of Science:

  • Ophthalmology
  • Neuroscience

Background:

  • The retinal pigment epithelium (RPE) supports photoreceptor function and optic nerve health.
  • Changes in the peripapillary RPE are observed in various ocular conditions, including glaucoma.

Purpose of the Study:

  • To investigate the occurrence and significance of peripapillary RPE changes in eyes with progressive glaucomatous cupping compared to non-glaucomatous and non-progressive glaucoma eyes.
  • To determine if observed RPE changes can account for characteristic optic disc features in glaucoma.

Main Methods:

  • Review of fundus photographs from patients with progressive glaucomatous cupping.
  • Comparison of RPE changes in glaucomatous eyes with those in non-progressive glaucoma and nonglaucomatous eyes.
  • Assessment of the frequency and degree of peripapillary RPE depigmentation or atrophy.

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Main Results:

  • Progressive RPE changes near the optic disc were observed in 21% of eyes with progressive glaucomatous cupping.
  • Similar RPE changes occurred naturally over time in 4% of non-progressive glaucoma eyes and 3% of nonglaucomatous eyes.
  • The observed RPE alterations in progressive glaucoma were infrequent and minor, insufficient to explain large optic disc haloes and crescents.

Conclusions:

  • Peripapillary RPE exhibits some progressive alteration in normal aging and can be affected during glaucomatous damage.
  • The RPE changes associated with glaucoma are not the primary cause of the extensive optic disc changes commonly seen in the disease.