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Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
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Polymeric nanoparticles for endodontic therapy.

Manuel Toledano1, Estrella Osorio1, Fátima S Aguilera1

  • 1University of Granada, Faculty of Dentistry, Dental Materials Section, Colegio Máximo de Cartuja S/n, Granada, 18071, Spain.

Journal of the Mechanical Behavior of Biomedical Materials
|February 25, 2020
PubMed
Summary
This summary is machine-generated.

Zinc-doped polymeric nanoparticles (Zn-NPs) effectively seal dentinal tubules, reduce permeability, and enhance remineralization in endodontically treated teeth. Zn-NPs offer superior mechanical reinforcement and sealing efficacy compared to other nanoparticle types.

Keywords:
EndodonticsMineralizationNanoDMANanoparticlesRamanSealing ability

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Area of Science:

  • Biomaterials Science
  • Dental Materials Science
  • Nanotechnology in Dentistry

Background:

  • Endodontic treatment can compromise root dentin integrity and increase permeability.
  • Novel polymeric nanoparticles (NPs) show potential for improving dentin sealing and remineralization.
  • Evaluating doped NPs for enhanced therapeutic effects in radicular dentin is crucial.

Purpose of the Study:

  • To assess the efficacy of various doped polymeric nanoparticles (NPs) in reducing dentin permeability.
  • To evaluate the potential of these NPs in facilitating dentin remineralization post-endodontic treatment.
  • To determine the optimal NP formulation for strengthening and sealing radicular dentin.

Main Methods:

  • Testing undoped, zinc-doped (Zn-NPs), calcium-doped (Ca-NPs), and doxycycline-doped (D-NPs) NPs on radicular dentin.
  • Assessing fluid filtration for microleakage and analyzing remineralization using advanced microscopy and material analysis techniques (SEM, TEM, AFM, XRD, Raman).
  • Evaluating mechanical properties including Young's modulus (Ei) and complex modulus.

Main Results:

  • Zn-NPs and Ca-NPs significantly reduced microleakage by sealing dentinal tubules.
  • Zn-NPs promoted superior dentin remineralization, increased Young's modulus (Ei), and favored crystallinity.
  • Ca-NPs closed tubules but resulted in mineral amorphization; undoped NPs and Ca-NPs did not mechanically reinforce dentin.

Conclusions:

  • Zinc-doped polymeric nanoparticles (Zn-NPs) demonstrate the highest efficacy in sealing, strengthening, and remineralizing endodontically treated root dentin.
  • Zn-NPs provide significant mechanical reinforcement by closing voids and enhancing dentin mineralization.
  • Application of Zn-NPs prior to canal filling is recommended for improved outcomes in endodontics.