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Ordo-Responsibility for Germline Gene Editing.

Robert Ranisch1,2, Tina Rudolph2, Hans-Joachim Cremer3

  • 1Institute of Ethics and History of Medicine, University of Tübingen, Tübingen, Germany.

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|February 25, 2020
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Summary
This summary is machine-generated.

International governance is needed for germline gene editing (GGE). This article proposes a global framework using "ordo-responsibilities," a pragmatic ethical approach grounded in human dignity and rights, for governing genome-editing technologies.

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Area of Science:

  • Bioethics
  • Genetics
  • International Law

Background:

  • The He Jiankui case of genetically modified twins underscores the urgent need for global oversight of germline gene editing (GGE).
  • Current scientific practices in genetics transcend national borders, necessitating international regulatory considerations.

Purpose of the Study:

  • To propose a global framework for the governance of germline gene editing (GGE).
  • To introduce and explain the concept of 'ordo-responsibilities' as a pragmatic ethical approach for international governance.
  • To contribute to the ongoing debate on regulating genome-editing technologies.

Main Methods:

  • Development of a global governance framework based on 'ordo-responsibilities'.
  • Explanation of the pragmatic nature of ordo-responsibility, emphasizing universal values (human dignity, rights) and achievable implementation.
  • Analysis of the complexities of cultural, ethical, legal, and anthropological convictions in global genetic science.

Main Results:

  • A proposed structure for an international rule-finding process for GGE.
  • An outlined pathway toward establishing an international framework for genome-editing technologies.
  • Identification of minimal requirements essential for global governance efforts.

Conclusions:

  • The case of He Jiankui highlights the critical need for international governance of germline gene editing (GGE).
  • Ordo-responsibilities offer a pragmatic, pluralistic ethical approach grounded in human dignity and rights for global GGE governance.
  • An international framework is essential to navigate the complexities of genome-editing technologies and ensure responsible scientific practice.