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Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding

Julia R Kardon1,2,3, Jamie A Moroco4, John R Engen4

  • 1Department of Biochemistry, Brandeis University, Waltham, United States.

Elife
|February 25, 2020
PubMed
Summary

Mitochondrial chaperone mtClpX activates 5-aminolevulinic acid synthase (ALAS) by targeted unfolding. This controlled remodeling, not global unfolding, is crucial for ALAS cofactor incorporation and function.

Keywords:
ALASClpXS. cerevisiaebiochemistrychaperonechemical biologyheme biosynthesismitochondriapyridoxal phosphate

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