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Updated: Dec 27, 2025
A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
Published on: December 5, 2016
6mA-Finder: a novel online tool for predicting DNA N6-methyladenine sites in genomes
Haodong Xu1, Ruifeng Hu1, Peilin Jia1
1School of Biomedical Informatics, Center for Precision Health.
Motivation:
DNA N6-methyladenine (6 mA) has recently been found as an essential epigenetic modification, playing its roles in a variety of cellular processes. The abnormal status of DNA 6 mA modification has been reported in cancer and other disease. The annotation of 6 mA marks in genome is the first crucial step to explore the underlying molecular mechanisms including its regulatory roles.
Results:
We present a novel online DNA 6 mA site tool, 6 mA-Finder, by incorporating seven sequence-derived information and three physicochemical-based features through recursive feature elimination strategy. Our multiple cross-validations indicate the promising accuracy and robustness of our model. 6 mA-Finder outperforms its peer tools in general and species-specific 6 mA site prediction, suggesting it can provide a useful resource for further experimental investigation of DNA 6 mA modification.
Availability And Implementation:
https://bioinfo.uth.edu/6mA_Finder.
Supplementary Information:
Supplementary data are available at Bioinformatics online.
