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Related Concept Videos

Proteomics01:33

Proteomics

9.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Globular and Fibrous Proteins02:21

Globular and Fibrous Proteins

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Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
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DNA Microarrays02:34

DNA Microarrays

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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Updated: Dec 27, 2025

Protocol for Plasmodium falciparum Infections in Mosquitoes and Infection Phenotype Determination
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Inferring Plasmodium vivax protein biology by using omics data.

D A Moreno-Pérez1, M A Patarroyo2

  • 1Molecular Biology and Immunology Department, Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera 50#26-20, Bogotá, Colombia; School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24#63C-69, Bogotá, Colombia; Animal Science Faculty, Universidad de Ciencias Aplicadas y Ambientales (U.D.C.A), Calle 222 No. 55-37, Bogotá, Colombia.

Journal of Proteomics
|February 25, 2020
PubMed
Summary

Understanding Plasmodium vivax parasite biology is difficult due to in vitro cultivation challenges. Recent advances in omic studies, including proteomics and immunomics, are improving knowledge for malaria control strategies.

Keywords:
Control methodsImmunomicsInteractomicsPlasmodium vivaxProteomics

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Area of Science:

  • Malariology
  • Parasitology
  • Molecular Biology

Background:

  • Plasmodium vivax presents significant challenges for in vitro cultivation, hindering research.
  • Advancements in non-human primate models and high-throughput analysis have overcome some of these limitations.
  • Understanding P. vivax biology is crucial for developing effective malaria control interventions.

Purpose of the Study:

  • To review the current state of omic studies in P. vivax research.
  • To highlight the contributions of proteomics, immunomics, and interatomics.
  • To discuss the potential of these omic approaches for disease control.

Main Methods:

  • Proteomics: analysis of the parasite's protein complement.
  • Immunomics: investigation of immune responses triggered by parasite molecules.
  • Interatomics: study of protein-protein interactions within the parasite.

Main Results:

  • Omic studies have significantly expanded knowledge of P. vivax protein composition.
  • Specific P. vivax molecules have been identified as capable of eliciting immune responses.
  • Key protein-protein interactions involved in parasite biology have been elucidated.

Conclusions:

  • Proteomics, immunomics, and interatomics are powerful tools for deciphering P. vivax biology.
  • These omic insights offer promising avenues for novel malaria diagnosis and treatment strategies.
  • Continued application of omic technologies will accelerate the development of P. vivax disease control methods.