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The immunopathogenesis of tuberculous pericarditis

Patrick Howlett1, Elsa Du Bruyn2, Hazel Morrison3

  • 1National Heart & Lung Institute, Imperial College London, Guy Scadding Building, Cale Street, London, SW3 6LY, United Kingdom; Department of Medicine, University of Cape Town, Observatory 7925, South Africa.

Microbes and Infection
|February 25, 2020
PubMed

Tuberculous pericarditis is a severe form of extrapulmonary tuberculosis and is the commonest cause of pericardial effusion in high incidence settings. Mortality ranges between 8 and 34%, and it is the leading cause of pericardial constriction in Africa and Asia. Current understanding of the disease is based on models derived from studies performed in the 1940-50s. This review summarises recent advances in the histology, microbiology and immunology of tuberculous pericarditis, with special focus on the effect of Human Immunodeficiency Virus (HIV) and the determinants of constriction.

Keywords:
ConstrictionHIVImmunologyPathogenesisPericardialTuberculosis

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