Therapeutic effects of shibashin misena® against fine-dust-induced pulmonary disorders in mice
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Zhenglin Piao1, Jae-Kuk Yoo2, Byeong-Wook Park2
1Department of Veterinary Surgery, College of Veterinary Medicine, Chonbuk University, Iksan, Jeollabuk-do, Republic of Korea.
Introduction:
In recent decades, fine-dust particulate matter (FM) has become a potential health hazard, causing various pathological respiratory disorders around the world. Inflammation induced by FM is regarded as a major cause of respiratory disorder in humans. The purpose of this study was to evaluate the therapeutic efficacy of Shibashin Misena®, a functional food composed of various bioactive ingredients, on FM-induced respiratory disorders in mice.
Materials And Methods:
Briefly, 40 mice were divided equally into four groups: normal controls (NC); FM-induced control group (FC); FM group treated with Shibashin Misena® 0.1 mL/head/day (FM0.1); FM group treated with Shibashin Misena® 0.2 mL/head/day (FM0.2).
Results:
FM significantly induced TNF-α, IL-17A, IL-1β, and TGF-β in bronchoalveolar lavage fluid (BALF) collected from the FM mice. Compared with FC, Shibashin Misena® decreased TNF-α, IL-17A, and IL-1β levels in BALF, and histopathologic evaluations revealed that Shibashin Misena® treatment significantly reduced inflammatory-cell infiltration and fibrosis related collagen deposition in lung tissue.
Conclusion:
This study demonstrated that Shibashin Misena® decreased FM-induced inflammation and fibrosis in lung tissue. Thus, Shibashin Misena® could be an effective supplement to prevent or improve FM-induced pulmonary disorders.
Insights
Shibashin Misena® effectively reduced inflammation and fibrosis in mouse lungs caused by fine dust (FM) exposure. This functional food shows promise for preventing or improving pulmonary disorders linked to air pollution.
Area of Science:
- Environmental Health
- Toxicology
- Pulmonology
Background:
- Fine dust (FM) particulate matter poses a significant global health risk, primarily causing respiratory disorders.
- Inflammation triggered by FM is a key factor in the development of human respiratory conditions.
- Investigating protective agents against FM-induced lung damage is crucial for public health.
Purpose of the Study:
- To assess the therapeutic effects of Shibashin Misena®, a functional food, on fine dust-induced respiratory issues in a mouse model.
- To determine if Shibashin Misena® can mitigate the inflammatory and fibrotic responses in the lungs.
Main Methods:
- Forty mice were allocated into four groups: normal controls, FM-induced controls, and two groups treated with different doses of Shibashin Misena® (0.1 mL/head/day or 0.2 mL/head/day).
- Mice were exposed to fine dust to induce respiratory conditions.
- Levels of inflammatory markers (TNF-α, IL-17A, IL-1β) in bronchoalveolar lavage fluid (BALF) and lung tissue histology were analyzed.
Main Results:
- Fine dust exposure significantly elevated inflammatory markers (TNF-α, IL-17A, IL-1β) and induced fibrosis in mouse lungs.
- Shibashin Misena® treatment notably reduced the levels of TNF-α, IL-17A, and IL-1β in BALF compared to the control group.
- Histopathological examination confirmed that Shibashin Misena® significantly decreased inflammatory cell infiltration and collagen deposition indicative of fibrosis in lung tissues.
Conclusions:
- Shibashin Misena® demonstrated a significant capacity to reduce both inflammation and fibrosis in the lungs of mice exposed to fine dust.
- These findings suggest that Shibashin Misena® can serve as a beneficial supplement for preventing or ameliorating pulmonary damage caused by fine dust exposure.
- Further research into Shibashin Misena®'s mechanisms and long-term effects is warranted.
