Related Experiment Video

Updated: Dec 27, 2025

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

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Molecular Signaling Pathways and Therapeutic Targets in Hepatocellular Carcinoma

Manali Dimri1, Ande Satyanarayana1

  • 1Department of Biochemistry and Molecular Biology, Molecular Oncology & Biomarkers Program, Georgia Cancer Center, Augusta University, Room-CN3144, 1410 Laney Walker Blvd., Augusta, GA 30912, USA.

Cancers
|February 26, 2020
PubMed

Insights

Hepatocellular carcinoma (HCC) involves complex signaling pathways. Targeting these pathways offers potential for novel therapeutics in HCC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Hepatocellular carcinoma (HCC) is frequently diagnosed at advanced stages, presenting limited treatment options.
  • Advances in molecular profiling reveal key signaling pathways driving HCC initiation and progression.

Purpose of the Study:

  • To review current understanding of signaling pathways in HCC development.
  • To identify potential therapeutic targets for HCC drug development.

Main Methods:

  • Literature review of signaling pathways implicated in HCC.
  • Analysis of molecular genetic profiling data related to HCC.

Main Results:

  • Identified critical pathways: receptor tyrosine kinase, Ras/Raf/MAPK, PI3K/AKT/mTOR, Wnt/β-catenin, ubiquitin/proteasome, and hedgehog signaling.
  • These pathways are crucial for HCC initiation and promotion.

Conclusions:

  • Targeting identified signaling pathways has led to novel HCC therapeutics.
  • Further research into these pathways can guide future drug development for HCC.
Keywords:
Hepatocellular carcinomasignaling pathwaytargeted therapy

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