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Microneedle-Facilitated Intradermal Proretinal Nanoparticle Delivery.
Benchaphorn Limcharoen1,2, Pattrawadee Toprangkobsin3, Marius Kröger2
1Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.
Nanomaterials (Basel, Switzerland)
|February 26, 2020
Summary
Microneedles loaded with proretinal nanoparticles (PRN) efficiently deliver retinal into the dermis. This novel transdermal system enhances retinal concentration in the skin, offering potential benefits for skin conditions.
Area of Science:
- Dermatology
- Nanotechnology
- Drug Delivery
Background:
- The stratum corneum acts as a barrier to transdermal drug delivery.
- Proretinal nanoparticles (PRN) can deliver retinal into the epidermis.
- Targeting the dermis requires advanced delivery systems.
Purpose of the Study:
- To combine microneedles (MN) and PRN for direct dermal delivery of retinal.
- To investigate microchannel formation, PRN localization, and skin healing kinetics.
- To compare dermal retinal concentration from PRN-loaded MN versus other retinal formulations.
Main Methods:
- Utilized non-invasive imaging techniques: dermoscopy, optical coherence tomography, and multiphoton tomography.
- Investigated microchannel formation and skin closure after MN application.
- Quantified retinal concentration in epidermis and dermis across different application forms.
Main Results:
- Confirmed microchannel formation by MN, with some persisting for over 24 hours.
- Observed PRN release from MN within the induced microchannels via multiphoton tomography.
- Demonstrated significantly higher retinal concentration in the dermis when using PRN-loaded microneedles.
Conclusions:
- PRN-loaded microneedles provide a rapid and efficient method for dermal retinal administration.
- This platform shows promise for treating skin conditions like atrophic scars and photo-aged skin.
- The combination of MN and PRN enhances transdermal drug delivery efficacy for retinal treatments.
