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Developmental Time Course of SNAP-25 Isoforms Regulate Hippocampal Long-Term Synaptic Plasticity and

Katisha R Gopaul1, Muhammad Irfan1,2, Omid Miry1

  • 1Department of Cell Biology & Anatomy, New York Medical College, Valhalla, NY 10595, USA.

International Journal of Molecular Sciences
|February 26, 2020
PubMed
Summary

Syntaxin-binding protein 25 (SNAP-25) isoforms influence brain plasticity. SNAP-25b deficiency impairs synaptic plasticity in young mice, but compensatory mechanisms in adults restore function, especially after learning.

Keywords:
SNARE proteinsSchaffer collateral-CA1 synapsescognitionlearning and memorylong-term depressionlong-term potentiation

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