Related Experiment Video

Updated: Dec 27, 2025

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

24.0K

[Research Progress of Epigenetics in Pathogenesis and Treatment of Malignant Tumors]

Pan Wang1, Honglin Zhao1, Fan Ren1

  • 1Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin Lung Cancer Institute, Tianjin Key Laboratory of lung Cancer Metastasis and Tumor Microenvironment, Tianjin 300052, China.

Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer
|February 26, 2020
PubMed

Insights

Epigenetic modifications influence tumor development. Epigenetic drugs, like DNA methyltransferase and histone deacetylase inhibitors, show promise in cancer treatment, especially in combination therapies.

Area of Science:

  • Oncology
  • Epigenetics
  • Pharmacology

Background:

  • Epigenetic modifications, including DNA methylation and histone modification, are integral to tumor occurrence and progression.
  • These epigenetic changes regulate gene function and expression, impacting cancer development.
  • Current epigenetic drugs face limitations, necessitating further research for broad clinical use.

Purpose of the Study:

  • To summarize the epigenetic mechanisms driving malignant tumors.
  • To review the progress of epigenetic drugs in cancer treatment.
  • To explore the potential of combination therapies involving epigenetic drugs.

Main Methods:

  • Review of epigenetic mechanisms in tumor development.
  • Analysis of current epigenetic drug classes (DNA methyltransferase inhibitors, histone deacetylase inhibitors).
  • Evaluation of preclinical and clinical data on epigenetic drug efficacy and limitations.

Main Results:

  • Epigenetic modifications play a crucial role in the pathogenesis of various cancers.
  • Epigenetic drugs demonstrate therapeutic potential but require further investigation due to existing shortcomings.
  • Combination therapies of epigenetic drugs with other anti-tumor agents exhibit significant promise.

Conclusions:

  • Understanding epigenetic mechanisms is key to developing novel cancer therapies.
  • Epigenetic drugs represent a growing area in oncology, with combination strategies offering enhanced efficacy.
  • Further research is essential to overcome limitations and expand the clinical application of epigenetic therapies.
Keywords:
Drug combinationsEpigenetic therapyEpigenomicsNeoplasms

More Related Videos

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

10.7K
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

6.0K

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.6K
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.3K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.6K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.5K
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K