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Role of Skin in Vitamin D Synthesis01:23

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Response to: Letter to the editor regarding: Real‑world rebound pattern of serum collagen type I C‑telopeptide after denosumab discontinuation and zoledronate rescue in postmenopausal osteoporosis and cancer treatment‑induced bone loss.

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Vitamin D supplementation: much ado about nothing.

D Gatti1, F Bertoldo2, G Adami1

  • 1Rheumatology Unit, University of Verona, Verona, Italy.

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
|February 26, 2020
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Summary

Recent studies question the benefits of vitamin D supplementation, contradicting earlier findings. This analysis examines new data to clarify the ongoing debate on vitamin D

Keywords:
Vitamin Dmeta-analysisosteoporosissupplementation

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Area of Science:

  • Endocrinology
  • Nutritional Science
  • Clinical Medicine

Background:

  • Scientific interest in vitamin D supplementation has surged in recent decades.
  • Despite increased research, expert consensus on clinical applications remains limited.
  • Conflicting evidence exists regarding vitamin D's benefits for skeletal and extra-skeletal health.

Discussion:

  • Analysis of recent clinical trials and meta-analyses on vitamin D supplementation.
  • Evaluation of data questioning the benefits of vitamin D for skeletal and extra-skeletal outcomes.
  • Reconciliation of contradictory findings in vitamin D research.

Key Insights:

  • Recent data challenge the established benefits of vitamin D supplementation.
  • Discrepancies exist between epidemiological observations and randomized controlled trial results.
  • Further investigation is needed to clarify vitamin D's role in health.

Outlook:

  • Future research directions to resolve current controversies in vitamin D supplementation.
  • Potential impact of updated findings on clinical guidelines and public health recommendations.
  • Clarifying the true efficacy of vitamin D for diverse health outcomes.