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Updated: Dec 27, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Exploring deprescribing opportunities for community pharmacists using the Behaviour Change Wheel
Clara Korenvain1, Linda D MacKeigan2, Katie N Dainty3
1Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, M5S 3M2, Canada; Women's College Hospital, 76 Grenville Street, Toronto, Ontario, M5S 1B2, Canada.
Community pharmacists face challenges in deprescribing, including understanding medication appropriateness, accessing patient data, and balancing demands. Enhancing their role requires targeted strategies and multi-stakeholder collaboration for safer medication use.
Area of Science:
- Pharmacology
- Health Services Research
- Qualitative Research
Background:
- Deprescribing, the process of reducing or stopping medications, aims to minimize harm from unnecessary drug use.
- Implementing deprescribing is complex for both patients and healthcare providers.
- The potential role of community pharmacists in deprescribing initiatives requires further investigation.
Purpose of the Study:
- To investigate the current involvement of community pharmacists in deprescribing practices.
- To identify effective strategies for improving and expanding pharmacists' contributions to deprescribing.
Main Methods:
- Qualitative telephone interviews were conducted with 17 community pharmacists in Ontario, Canada.
- The Behaviour Change Wheel's COM-B model guided interview question development.
- Inductive thematic analysis was employed, with initial coding by multiple investigators and subsequent analysis informed by the Behaviour Change Wheel.
Main Results:
- Pharmacist engagement in deprescribing is influenced by their knowledge of appropriate medications for discontinuation, access to patient health information, and competing clinical and operational demands.
- Key barriers include understanding which medications to stop, patient information accessibility, and daily practice pressures.
- Recommendations focus on defining the pharmacist's role, enhancing their understanding of deprescribing integration, and engaging multiple stakeholders.
Conclusions:
- This study provides novel insights into real-world challenges faced by community pharmacists in deprescribing.
- Theory-informed recommendations are presented to optimize pharmacist involvement in deprescribing.
- Findings highlight the need for structured approaches and collaboration to enhance community pharmacists' contributions to deprescribing.
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