Related Experiment Video

Updated: Dec 27, 2025

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
06:08

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

2.3K

Oxidative stress is associated with atopic indices in relation to childhood rhinitis and asthma

Cheryn Yu Wei Choo1, Kuo-Wei Yeh2, Jing-Long Huang2

  • 1College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|February 26, 2020
PubMed

Insights

Oxidative stress markers correlate with allergic indices in children, influencing allergic responses and atopic disease risk. Specific markers link to allergic rhinitis and asthma development.

Area of Science:

  • Immunology
  • Environmental Health
  • Pediatrics

Background:

  • The link between oxidative stress and atopic diseases remains unclear.
  • Existing research identifies risk factors for atopic diseases but lacks comprehensive analysis of oxidative stress markers and atopic indices.

Purpose of the Study:

  • To investigate the association between oxidative stress markers and atopic indices in a pediatric birth cohort.
  • To explore the relationship between oxidative stress, allergic sensitization, and the risk of developing atopic diseases.

Main Methods:

  • A 7-year follow-up of 132 children from a birth cohort.
  • Measurement of oxidative stress markers: plasma glutathione peroxidase (GPx), myeloperoxidase (MPO), total antioxidant capacity (TAC), and urine 8-hydroxy-2'-deoxyguanosine (8-OHdG).
  • Assessment of allergic indices: allergen-specific IgE, fractional exhaled nitric oxide (FeNO), and pulmonary function tests.

Main Results:

  • GPx and MPO levels showed inverse correlations with food (shrimp, crab) and house dust mite sensitization, respectively.
  • 8-OHdG levels were negatively correlated with FeNO levels (p < 0.01).
  • TAC levels positively correlated with FVC and FEV1 predicted values (p < 0.05).
  • While not directly associated with atopic disease risk, specific marker-sensitization/index pairs were linked to increased risk of allergic rhinitis (GPx-crab, 8-OHdG-FeNO) and asthma (MPO-mite, TAC-pulmonary function).

Conclusions:

  • Oxidative stress markers are significantly correlated with various allergic indices.
  • These correlations suggest a role for oxidative stress in modulating allergic responses and contributing to the development of atopic diseases.
Abstract

Keywords:
AsthmaAtopic indicesChildrenOxidative stressRhinitis

More Related Videos

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.7K
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.4K

Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.3K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.9K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.1K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.1K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
288
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.2K