Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple gas washout during jet ventilation.

G G Berdine1, J L Lehr, P J Strollo

  • 1Department of Medicine, University of Texas Health Sciences Center, Audie L. Murphy Memorial Veterans Hospital, San Antonio.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|November 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Why the upper airway is not like a gall bladder.

Chest·1999
Same author

Medical management of obstructive sleep apnea.

Progress in cardiovascular diseases·1999
Same author

The influence of craniofacial structure on obstructive sleep apnea in young adults.

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons·1998
Same author

Positive pressure therapy.

Clinics in chest medicine·1998
Same author

Electrocardiogram trace paradoxically filtered by activation of an electrosurgical unit.

Journal of clinical monitoring·1998
Same author

Fractional changes in lung capillary blood volume and oxygen saturation during the cardiac cycle in rabbits.

Journal of applied physiology (Bethesda, Md. : 1985)·1997
Same journal

Thoroughbred horses susceptible to Recurrent Exertional Rhabdomyolysis have elevated skeletal muscle mitochondrial capacities.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Change in Neutrophil-to-Lymphocyte Ratio after acute and chronic exercise: A Systematic Review and Meta-Analysis.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Ankylosing spondylitis and muscle sympathetic nerve activity: a case study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Intracranial vasomotor and blood flow responses to light intensity aerobic exercise in young adults: a 4D flow MRI study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Comparative assessments of the COSMED adaptive mixing chamber vs. breath-by-breath methods for oxygen uptake measurements in recreationally active adults.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Can we assess exercise metabolism from skin? Metabolomic profiles in skin dialysate collected during exercise.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
See all related articles

Gas washout patterns during jet ventilation differ with tidal volume. Smaller volumes reveal a two-phase decay, indicating slower diffusion from the lungs, impacting gas clearance in airways.

Area of Science:

  • Physiology
  • Respiratory Mechanics
  • Gas Transport

Background:

  • Jet ventilation is a method used in respiratory support.
  • Understanding gas washout dynamics is crucial for optimizing ventilation strategies.
  • Previous models did not fully capture the complex gas transport during low tidal volume ventilation.

Purpose of the Study:

  • To investigate the gas washout kinetics of helium (He), nitrogen (N2), and sulfur hexafluoride (SF6) during jet ventilation.
  • To determine how tidal volume affects gas washout patterns and diffusion.
  • To elucidate the underlying transport mechanisms influencing gas clearance in the airways.

Main Methods:

  • Simultaneous washout of He, N2, and SF6 was monitored during jet ventilation in six baboons.

Related Experiment Videos

  • Tidal volumes ranged from 50-200 ml at rates of 1-2 Hz.
  • Gas concentrations were measured via mass spectrometry from the trachea and a lower lobe bronchus.

    • Main Results:

    • Large tidal volumes resulted in single exponential decay, with He clearing fastest and SF6 slowest.
    • Smaller tidal volumes showed a two-phase decay: a fast phase (SF6 fastest, He slowest) and a slow phase (He fastest, SF6 slowest).
    • The initial phase magnitude was smaller in the lower lobe bronchus compared to the trachea, suggesting diffusion limitation.

    Conclusions:

    • Gas washout during jet ventilation exhibits complex, volume-dependent behavior.
    • A serial two-compartment model with diffusion limitation explains the observed patterns.
    • Slower alveolar to central airway transport, not central airway to opening, drives initial clearance differences.