Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanical Protein Functions01:58

Mechanical Protein Functions

5.4K
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
5.4K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

3.3K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
3.3K
Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

3.4K
The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
3.4K
Cell Migration01:09

Cell Migration

18.3K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
18.3K
Cell Migration01:19

Cell Migration

6.2K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transbronchial photodynamic therapy for peripheral lung cancer - A pilot study.

Photodiagnosis and photodynamic therapy·2026
Same author

Evaluating the effects of CD8/CD4 on T cell function in terms of TCR-pMHC-coreceptor catch and slip bonds.

bioRxiv : the preprint server for biology·2026
Same author

Mechanomedicine: Translating mechanical forces into therapeutic strategies.

APL bioengineering·2025
Same author

Direct Binding of Lyn to GPIbβ Transmits 2-Way GPIb-IX Signaling to Stimulate Platelet Activation and VWF Binding.

Circulation research·2025
Same author

Development of Pd-Loaded Hf-Based Metal-Organic Framework as a Dual-Modal Contrast Agent for Photoacoustic Imaging and Computed Tomography.

ACS biomaterials science & engineering·2025
Same author

Assessing ChatGPT for Clinical Decision-Making in Radiation Oncology, With Open-Ended Questions and Images.

Practical radiation oncology·2025

Related Experiment Video

Updated: Dec 27, 2025

Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System
09:56

Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System

Published on: December 23, 2022

2.0K

From cellular to molecular mechanobiology.

Cheng Zhu, Cho-Yin Lee, Larry V McIntire

    APL Bioengineering
    |February 26, 2020
    PubMed
    Summary

    Cellular mechanobiology examines cell phenotypes in response to mechanical forces. This perspective connects cellular and molecular mechanobiology, exploring how physical forces impact intracellular proteins and cellular functions.

    Area of Science:

    • Cellular and Molecular Mechanobiology
    • Biophysics
    • Biochemistry

    Background:

    • Mechanobiology investigates cellular phenotypes and adaptations to mechanical environments.
    • Molecular mechanobiology explores the mechanisms by which cells sense and respond to mechanical cues.
    • Understanding the interplay between cellular and molecular responses to mechanical stimuli is crucial.

    Purpose of the Study:

    • To bridge the gap between cellular and molecular mechanobiology.
    • To illustrate the connection using research inspired by Professor Shu Chien's work.
    • To discuss the impact of physical forces on intracellular proteins and cellular functions.

    Main Methods:

    • Review of existing research and collaborative work.
    • Analysis of how physical forces affect protein conformation and interactions.

    More Related Videos

    Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption
    09:20

    Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption

    Published on: October 4, 2019

    5.8K
    A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro
    09:50

    A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro

    Published on: August 27, 2015

    8.5K

    Related Experiment Videos

    Last Updated: Dec 27, 2025

    Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System
    09:56

    Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System

    Published on: December 23, 2022

    2.0K
    Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption
    09:20

    Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption

    Published on: October 4, 2019

    5.8K
    A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro
    09:50

    A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro

    Published on: August 27, 2015

    8.5K
  • Exploration of mechanotransduction pathways.

    • Main Results:

    • Physical forces acting on intracellular proteins can alter protein conformation and interactions.
    • These alterations can crosstalk with biochemical signaling pathways.
    • Mechanotransduction processes can lead to changes in cell structure and function.

    Conclusions:

    • Physical forces play a significant role in regulating cellular phenotypes at both molecular and cellular levels.
    • Connecting molecular events to cellular outcomes provides a comprehensive understanding of mechanobiology.
    • Further research in this interdisciplinary field holds promise for understanding health and disease.