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Immature tendon adaptation to strenuous exercise.

S L Curwin1, A C Vailas, J Wood

  • 1Department of Kinesiology, University of California, Los Angeles 90024-1568.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|November 1, 1988
PubMed
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High-intensity exercise in young chickens increases oxygen consumption and tendon collagen deposition. However, it also reduces tendon collagen maturation, indicating greater matrix turnover during growth.

Area of Science:

  • Exercise physiology
  • Biochemistry
  • Connective tissue biology

Background:

  • Tendon adaptation to mechanical loading is crucial for musculoskeletal health.
  • Understanding the impact of exercise intensity on developing tendons is important for optimizing training regimens.
  • Previous research has explored exercise effects on muscle, but tendon-specific responses, especially during growth, require further investigation.

Purpose of the Study:

  • To investigate the effects of a progressive treadmill running program on tendon collagen metabolism in young White Leghorn roosters.
  • To determine if high-intensity exercise influences collagen deposition, concentration, and cross-linking in developing tendons.
  • To assess the impact of exercise on maximal oxygen consumption (VO2 max) and related enzymatic activity.

Main Methods:

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  • White Leghorn roosters were divided into runner and control groups.
  • Runners underwent an 8-week progressive treadmill running program at 70-80% of maximal oxygen consumption (VO2 max).
  • Tendon collagen deposition, DNA, proteoglycan, collagen concentrations, dry weight, and pyridinoline cross-links were analyzed.

Main Results:

  • The running group showed a significant 51% increase in gastrocnemius fumarase activity and a 21% increase in VO2 max.
  • Tendon collagen deposition increased by 46% in runners, with no changes in DNA, proteoglycan, or collagen concentrations or tendon dry weight.
  • Tendon collagen from runners exhibited 50% fewer pyridinoline cross-links, suggesting reduced collagen maturation.

Conclusions:

  • High-intensity exercise in growing chickens stimulates increased matrix-collagen turnover in tendons.
  • This enhanced turnover leads to a reduction in the maturation of tendon collagen.
  • These findings highlight a potential trade-off between exercise-induced adaptations and tendon maturation during development.