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Traditional and Digital Biomarkers: Two Worlds Apart?

Lmar M Babrak1, Joseph Menetski2, Michael Rebhan3,4

  • 1FHNW University of Applied Sciences Northwestern Switzerland, Muttenz, Switzerland.

Digital Biomarkers
|February 26, 2020
PubMed
Summary
This summary is machine-generated.

Digital biomarkers from mobile health apps offer new insights but require clear definitions and validation. This study addresses challenges to advance their use in precision medicine.

Keywords:
Biomarker classificationDigital biomarkersDigital healthSemanticsTraditional biomarkers

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Area of Science:

  • Biomedical informatics
  • Digital health
  • Precision medicine

Background:

  • Biomarkers are crucial in medicine, with digital devices generating vast health data.
  • The rise of mobile health apps creates new, complex datasets for biomarker discovery.
  • Unclear definitions and validation issues hinder the progress of digital biomarkers.

Purpose of the Study:

  • To identify challenges in digital biomarker research and propose solutions.
  • To synchronize semantics and define features of digital vs. traditional biomarkers.
  • To explore novel applications for digital biomarkers in precision medicine.

Main Methods:

  • Convened the DayOne Workshop with academic and industry experts.
  • Analyzed similarities and differences between traditional and digital biomarkers.
  • Reviewed current regulatory frameworks and identified novel applications.

Main Results:

  • Identified key issues hindering digital biomarker discovery and validation.
  • Proposed strategies for semantic synchronization and feature definition.
  • Highlighted the potential of digital biomarkers for advancing precision medicine.

Conclusions:

  • Addressing definitional and validation challenges is critical for digital biomarker adoption.
  • Standardization and regulatory clarity will accelerate the integration of digital biomarkers.
  • Digital biomarkers hold significant promise for personalized healthcare and precision medicine.