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Post-Transplantation Diabetes Mellitus.

Syed Haris Ahmed1, Kathryn Biddle2, Titus Augustine3

  • 1Countess of Chester Hospital NHS Foundation Trust, Chester, UK. asyedharis76@gmail.com.

Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders
|February 26, 2020
PubMed
Summary

Post-transplantation diabetes mellitus (PTDM) affects 10-40% of solid organ transplant recipients due to immunosuppression. This review details PTDM

Keywords:
Calcineurin inhibitorsDiabetes mellitusGraft failureMacrovascularMicrovascularMortalityPost-transplantationRejectionSteroidsmTOR inhibitors

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Area of Science:

  • Nephrology
  • Endocrinology
  • Immunology

Background:

  • Solid organ transplantation (SOT) is a vital treatment for end-stage organ dysfunction.
  • Long-term immunosuppression post-SOT increases risks of infections, cardiovascular disease, and mortality.
  • Post-transplantation diabetes mellitus (PTDM) is a significant complication with incidence rates ranging from 10% to 40%.

Purpose of the Study:

  • To provide a comprehensive review of PTDM.
  • To examine the pathogenesis, diagnostic criteria, and management strategies for PTDM.
  • To discuss therapeutic options considering safety and drug-drug interactions with immunosuppressants.

Main Methods:

  • Literature review of current evidence on PTDM.
  • Analysis of diagnostic criteria evolution.
  • Evaluation of therapeutic interventions for PTDM management.

Main Results:

  • PTDM incidence varies significantly across studies (10-40%).
  • Distinct pathophysiology and clinical course differentiate PTDM from type 2 diabetes.
  • Management requires careful consideration of immunosuppressive agents and potential interactions.

Conclusions:

  • PTDM poses a considerable challenge in post-transplant care.
  • Tailored therapeutic approaches are essential for optimal glycemic control and transplant outcomes.
  • Understanding PTDM's unique aspects is crucial for effective patient management.