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Tau PET Imaging.

Makoto Higuchi1

  • 1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan. higuchi.makoto@qst.go.jp.

Advances in Experimental Medicine and Biology
|February 26, 2020
PubMed
Summary
This summary is machine-generated.

New imaging agents detect Alzheimer's disease (AD) tau aggregates and other tauopathies. A novel radiocompound offers high contrast for diverse tau pathologies, aiding individual diagnosis.

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Area of Science:

  • Neuroscience
  • Radiochemistry
  • Medical Imaging

Background:

  • Fibrillar tau aggregates are hallmarks of Alzheimer's disease (AD) and other tauopathies.
  • Understanding tau pathology is crucial for diagnosing and treating neurodegenerative disorders.
  • Existing positron emission tomography (PET) tracers for tau fibrils have limitations, including off-target binding and poor detection of non-AD tauopathies.

Purpose of the Study:

  • To develop and evaluate novel imaging agents for detecting tau aggregates in the brain.
  • To overcome the limitations of existing tau PET tracers.
  • To enable sensitive and specific diagnosis of diverse tauopathies.

Main Methods:

  • Development of novel radiochemical compounds for PET imaging.
  • Clinical evaluation of 'second-generation' tau PET probes.
  • Assessment of tracer performance in capturing AD-type and non-AD tau deposits.

Main Results:

  • Initial tau PET tracers showed utility for AD tau but had off-target binding and limited sensitivity for non-AD tauopathies.
  • Second-generation tracers demonstrated improved specificity for AD tau pathologies.
  • A novel radiocompound developed by the research group achieved high contrast for both AD and non-AD tau aggregates.

Conclusions:

  • Advanced tau PET probes are essential for accurate diagnosis and understanding of tauopathies.
  • The novel radiocompound shows promise for individual diagnostic evaluations across various tauopathies.
  • Improved imaging agents can facilitate earlier diagnosis and guide therapeutic strategies for neurodegenerative diseases.