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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

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The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
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Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

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Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
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Amines can behave as Brønsted–Lowry bases by accepting a proton from the acid to form corresponding conjugate acids. Due to a lone pair of nonbonding electrons, aliphatic amines can also act as Lewis bases by forming a covalent bond with an electrophile.
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Structure-Properties Relationship in the Evaluation of Alginic Acid Functionality for Tableting.

Rihab Benabbas1, Noelia M Sanchez-Ballester1, Bernard Bataille1

  • 1ICGM, University Montpellier, CNRS, ENSCM, Montpellier, France.

AAPS Pharmscitech
|February 26, 2020
PubMed
Summary

Alginic acid

Keywords:
alginic aciddirect compressiondisintegrationphysicochemical characterizationswelling force

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Alginic acid is a polysaccharide with potential applications in direct compression tablet formulations.
  • Understanding its structural and molecular properties is crucial for optimizing tablet performance.

Purpose of the Study:

  • To investigate the relationship between alginic acid's properties and its direct compression characteristics.
  • To evaluate alginic acid as a potential filler excipient in tablet formulations.

Main Methods:

  • Characterization of alginic acid using X-ray powder diffraction, spectroscopy, thermal analysis, microscopy, NMR, chromatography, and rheology.
  • Assessment of tabletability, compressibility, elasticity, deformation, and disintegration.

Main Results:

  • Molecular weight significantly impacts tablet hardness and elastic recovery.
  • Alginic acid with lower molecular weight yielded harder tablets with reduced elasticity.
  • Disintegration properties were comparable to commercial superdisintegrants.

Conclusions:

  • Alginic acid shows promise as a filler excipient for direct compression.
  • Determining alginic acid's molecular weight is critical for reproducible tablet strength.