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Related Experiment Video

Updated: Dec 27, 2025

Measuring Motor Coordination in Mice
10:07

Measuring Motor Coordination in Mice

Published on: May 29, 2013

101.9K

Using a mouse model to gain insights into developmental coordination disorder.

Kamaldeep K Gill1,2, Jeffy Rajan Soundara Rajan3,4, Daniel Goldowitz2,3,4

  • 1Rehabilitation Sciences, University of British Columbia, Vancouver, Canada.

Genes, Brain, and Behavior
|February 26, 2020
PubMed
Summary

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This summary is machine-generated.

Developmental Coordination Disorder (DCD) affects motor skills in many children. This study introduces a mouse model to investigate DCD

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Motor impairments are prevalent in neurodevelopmental disorders, affecting over 50% of children with ADHD or ASD.
  • Developmental Coordination Disorder (DCD) is a neurodevelopmental condition impacting motor coordination and learning, with unknown causes.
  • Animal models are crucial for understanding the behavioral and mechanistic aspects of motor control.

Purpose of the Study:

  • To present a novel mouse model for studying Developmental Coordination Disorder (DCD).
  • To gain behavioral and genetic insights into the underlying causes of DCD.
  • To establish a model with high face, construct, and predictive validity for DCD research.

Main Methods:

  • Utilizing pre-clinical and clinical expertise to develop the mouse model.
Keywords:
BXDbehavioral assaydevelopmental coordination disordermotor coordinationmotor learningmotor skills disorderpre-clinical modelquantitative trait loci

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  • Establishing specific scientific criteria for the model's validity.
  • Employing behavioral analysis and genetic investigation in mice.

    • Main Results:

    • The study outlines the methodology for a new mouse model of DCD.
    • The model is designed to meet rigorous scientific criteria for validity.
    • This approach facilitates the investigation of DCD's potential causes.

    Conclusions:

    • The developed mouse model offers a robust platform for DCD research.
    • This model aids in understanding the behavioral and genetic underpinnings of DCD.
    • Further investigation using this model can elucidate the etiology of DCD.