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Updated: Dec 27, 2025
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Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
Published on: July 23, 2020
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Voltammetry of local anesthetics: theoretical and practical aspects
Solomiya Pysarevska1, Serhiy Plotycya2,3, Liliya Dubenska2
1Life Safety Department, Ivan Franko National University of Lviv, Lviv, Ukraine.
Critical Reviews in Analytical Chemistry
|February 26, 2020
Summary
Voltammetric methods offer a sensitive and selective approach for determining local anesthetics (LAs) in pharmaceutical and biological samples. This review highlights their advantages over other techniques for analyzing common LAs like lidocaine.
Area of Science:
- Analytical Chemistry
- Electrochemistry
Background:
- Local anesthetics (LAs) are crucial in various medical fields but can cause adverse effects.
- Existing chromatographic and spectroscopic methods for LA determination have limitations.
Purpose of the Study:
- To review the capabilities and benefits of voltammetric methods for local anesthetic determination.
- To compare voltammetry with other analytical techniques for LAs.
Main Methods:
- Review of published literature on voltammetric, chromatographic, and spectroscopic methods for LA analysis.
- Analysis of electrochemical behavior and transformation mechanisms of LAs on different electrodes.
- Evaluation of analytical parameters including sensitivity, selectivity, and reproducibility.
Main Results:
- Voltammetric methods demonstrate high sensitivity and selectivity for LA determination.
- The review covers electrochemical oxidation and reduction mechanisms of common LAs (benzocaine, lidocaine, procaine).
- Voltammetry is effective for analyzing LAs in pharmaceutical formulations and biological fluids.
Conclusions:
- Voltammetric methods present significant advantages for the accurate and efficient determination of local anesthetics.
- These electrochemical techniques are valuable tools for quality control and pharmacokinetic studies of LAs.
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