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Comparative study between pSWE and 2D-SWE techniques integrated in the same ultrasound machine, with Transient

Camelia Gianina Foncea1, Alina Popescu2, Raluca Lupusoru3

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Point Shear Wave Elastography (pSWE) and 2D Shear Wave Elastography (2D-SWE) are feasible for assessing liver fibrosis. These methods show strong correlations with Transient Elastography (TE) results, offering reliable non-invasive liver stiffness measurements.

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Area of Science:

  • Hepatology
  • Medical Imaging
  • Diagnostic Ultrasound

Background:

  • Liver fibrosis (LF) assessment is crucial for managing chronic liver diseases.
  • Non-invasive methods for LF assessment are increasingly important.
  • Transient Elastography (TE) is a reference method, but alternative elastographic techniques are being explored.

Purpose of the Study:

  • To evaluate the feasibility of point Shear Wave Elastography (pSWE) and 2D Shear Wave Elastography (2D-SWE) for liver fibrosis assessment.
  • To compare pSWE and 2D-SWE with Transient Elastography (TE) as the reference method.
  • To assess the diagnostic performance of pSWE and 2D-SWE in classifying liver fibrosis severity.

Main Methods:

  • A study including 115 subjects where liver fibrosis was assessed using TE, pSWE, and 2D-SWE in the same session.
  • Defined reliable measurements for TE (IQR/M ≤30%) and for pSWE/2D-SWE (RMI ≥0.5 and IQR/M ≤30%).
  • Used TE cut-offs for LF classification: F2 ≥7kPa, F3 ≥9.5kPa, and F4 ≥12kPa.

Main Results:

  • Reliable measurements were obtained in 98.2% of TE, 93.9% of pSWE, and 92.1% of 2D-SWE cases, with the final analysis including 101 patients.
  • Strong correlations were observed between TE and 2D-SWE (r=0.85), TE and pSWE (r=0.88), and pSWE and 2D-SWE (r=0.90).
  • pSWE and 2D-SWE demonstrated high diagnostic accuracy for LF staging, with AUROCs ranging from 0.93 to 0.98.

Conclusions:

  • Point Shear Wave Elastography (pSWE) and 2D Shear Wave Elastography (2D-SWE) are feasible and reliable methods for liver fibrosis assessment.
  • Both pSWE and 2D-SWE show strong correlations with Transient Elastography (TE) results.
  • These advanced elastographic techniques offer a promising non-invasive approach for evaluating liver stiffness and fibrosis.