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Microcin H47: A Class IIb Microcin with Potent Activity Against Multidrug Resistant Enterobacteriaceae
Jacob D Palmer1, Benedikt M Mortzfeld1,2,3, Emma Piattelli2
1Department of Bioengineering, University of Massachusetts Dartmouth, 285 Old Westport Road, N. Dartmouth, Massachusetts 02747-2300, United States.
ACS Infectious Diseases
|February 26, 2020
Summary
Microcin H47 (MccH47) effectively inhibits a broad range of enteric bacteria, including multidrug-resistant strains. This antimicrobial peptide shows promise for treating challenging enteric infections.
Area of Science:
- Microbiology
- Antimicrobial Peptides
Background:
- Microcin H47 (MccH47), an antimicrobial peptide from *Escherichia coli*, has shown potential in engineered probiotics.
- Previous studies reported conflicting results regarding MccH47's inhibitory activity against *Salmonella* species.
Discussion:
- This study clarifies MccH47's activity spectrum by purifying and testing MccH47-monoglycosylated enterobactin (MccH47-MGE).
- Minimum inhibitory concentrations (MICs) were determined for medically relevant *Enterobacteriaceae*, including *Salmonella* and multidrug-resistant (MDR) strains.
Key Insights:
- Contrary to prior assumptions, MccH47 exhibits broad and potent activity against the *Enterobacteriaceae* family.
- The peptide's efficacy extends to numerous multidrug-resistant strains, challenging previous narrow-spectrum assessments.
Outlook:
- MccH47 demonstrates significant potential as a therapeutic candidate for combating MDR enteric infections.
- Further development of MccH47 is warranted based on its broad-spectrum antimicrobial properties.
Keywords:
Salmonellaantimicrobial peptideantimicrobial resistancemicrocinminimum inhibitory concentrationpurificationMore Related Videos
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