Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

130
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
130
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

167
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
167
Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

433
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
433
Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug01:14

Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug

156
In pharmacotherapy, monitoring drug concentrations is paramount, especially for drugs whose therapeutic effects hinge on both the active compound and its metabolite. Hepatic impairment profoundly influences drug potency by altering liver function. If the drug is more potent than its metabolite, impaired liver function amplifies drug activity due to elevated drug concentration levels. Conversely, if the metabolite holds greater potency, diminished liver function diminishes drug activity by...
156
Liver Physiology01:30

Liver Physiology

3.4K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.4K
Liver Histology01:27

Liver Histology

3.9K
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence of liver fibrosis in the general population (the LiverScreen project): a multinational European cohort study.

Lancet (London, England)·2026
Same author

An Exploration of the Views and Perspectives of Australian Trans and Gender Diverse Individuals About Transvaginal Ultrasound.

Perspectives on sexual and reproductive health·2026
Same author

Role of Endoscopic Ultrasound in the Diagnosis and Management of Liver Diseases.

Journal of clinical medicine·2025
Same author

Addition of Dendritic Cell Vaccination to Conditioning Cyclophosphamide and Chemoembolization in Patients with Hepatocellular Carcinoma: The ImmunoTACE Trial.

Clinical cancer research : an official journal of the American Association for Cancer Research·2025
Same author

The value of cholangioscopy-guided bite-on-bite (-on bite) biopsies in indeterminate biliary duct strictures.

Endoscopy·2025
Same author

The interrelationship between women's help-seeking experiences for vaginismus and their sense of self: a qualitative study and abductive analysis.

Health psychology and behavioral medicine·2024
Same journal

Beyond the High: A Narrative Review of the Chronic Complications of Recreational Ketamine Use.

British journal of hospital medicine (London, England : 2005)·2026
Same journal

Prolonged Undiagnosed Prodromal Symptoms.

British journal of hospital medicine (London, England : 2005)·2026
Same journal

Human Factors and Deterioration: What Success Factors Facilitate Escalation of Care and How Can These Be Applied More Reliably?

British journal of hospital medicine (London, England : 2005)·2026
Same journal

Comparative Evaluation of Functional Outcomes and Postoperative Complications After Minimally Invasive Fixation for Acromioclavicular Joint Injuries.

British journal of hospital medicine (London, England : 2005)·2026
Same journal

A Systematic Review of Functional MRI Studies on Seasonal Modulation of Brain Functional Connectivity.

British journal of hospital medicine (London, England : 2005)·2026
Same journal

More Than Myocarditis? Cardiac Involvement in Phaeochromocytoma-A Case Report.

British journal of hospital medicine (London, England : 2005)·2026
See all related articles

Related Experiment Video

Updated: Dec 27, 2025

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides
08:39

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides

Published on: September 16, 2020

8.4K

Detecting chronic liver disease: are liver function tests the solution?

Prarthana Thiagarajan1,2,3, Jane Chalmers1,2,3, Indra N Guha1,2,3

  • 1NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK.

British Journal of Hospital Medicine (London, England : 2005)
|February 26, 2020
PubMed
Summary
This summary is machine-generated.

Chronic liver disease is a growing UK health crisis, surpassing heart disease in lost working years. Early detection of liver fibrosis is crucial for intervention and improved outcomes.

Keywords:
BiomarkersChronic liver diseaseCommissioned pathwayFibrosis detectionPrimary care

More Related Videos

Author Spotlight: Advancing Hepatic Fibrosis Diagnosis Using Magnetic Resonance Elastography and AI
06:09

Author Spotlight: Advancing Hepatic Fibrosis Diagnosis Using Magnetic Resonance Elastography and AI

Published on: July 21, 2023

1.7K
A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia
09:12

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

Published on: February 3, 2023

3.1K

Related Experiment Videos

Last Updated: Dec 27, 2025

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides
08:39

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides

Published on: September 16, 2020

8.4K
Author Spotlight: Advancing Hepatic Fibrosis Diagnosis Using Magnetic Resonance Elastography and AI
06:09

Author Spotlight: Advancing Hepatic Fibrosis Diagnosis Using Magnetic Resonance Elastography and AI

Published on: July 21, 2023

1.7K
A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia
09:12

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

Published on: February 3, 2023

3.1K

Area of Science:

  • Hepatology
  • Epidemiology
  • Public Health

Background:

  • Chronic liver disease (CLD) is projected to become the leading cause of working life years lost in the UK by 2020.
  • Aetiology is shifting from infectious to non-communicable causes, with non-alcoholic fatty liver disease (NAFLD) affecting 25% of UK adults, linked to obesity and type 2 diabetes.
  • Rising alcohol consumption also contributes significantly to CLD burden in working-age adults.

Purpose of the Study:

  • To address the urgent need for early identification of individuals with CLD.
  • To highlight the critical role of liver fibrosis as a predictor of adverse clinical outcomes.
  • To review current diagnostic challenges and explore innovative, non-invasive methods for community-based CLD diagnosis and stratification.

Main Methods:

  • Critique of standard liver function tests (LFTs).
  • Discussion of emerging non-invasive biomarkers for liver fibrosis.
  • Review of advanced imaging technologies for CLD assessment.

Main Results:

  • Standard LFTs have limitations in detecting early-stage CLD.
  • Non-invasive biomarkers and advanced imaging show promise for accurate fibrosis detection.
  • Early fibrosis detection is key to timely intervention and improved patient prognosis.

Conclusions:

  • There is a critical need for accessible, non-invasive methods to detect liver fibrosis in at-risk populations.
  • Novel biomarkers and imaging techniques offer potential to revolutionize early CLD diagnosis and management.
  • Earlier identification and intervention strategies are essential to mitigate the growing impact of CLD on public health.