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Accurate automated leucocyte differential counts despite profound leucopenia
1Middlesex Hospital, London.
Journal of Clinical Pathology
|November 1, 1988
Summary
The Technicon H*1 Autoanalyser accurately performs differential white cell counts in low white blood cell count samples. This automated method provides reliable results comparable to manual microscopy, enabling confident reporting.
Area of Science:
- Hematology
- Clinical Pathology
- Laboratory Automation
Background:
- Accurate differential white cell counts are crucial for diagnosing and monitoring various medical conditions.
- Profoundly leucopenic specimens present challenges for automated hematology analyzers.
- Manual differential counting is the gold standard but is labor-intensive and time-consuming.
Purpose of the Study:
- To evaluate the accuracy and reliability of the Technicon H*1 Autoanalyser for differential white cell counts in leucopenic blood samples.
- To compare the performance of the H*1 Autoanalyser with manual differential counting methods.
Main Methods:
- Differential white cell counts were generated using the Technicon H*1 Autoanalyser.
- Manual differential counts were performed on peripheral blood smears stained with May-Grünwald-Giemsa stain.
- Results from both methods were statistically correlated.
Main Results:
- A high degree of correlation was observed between the H*1 Autoanalyser and manual differential white cell counts.
- The automated counts were deemed reliable for reporting even in cases of profound leucopenia.
Conclusions:
- The Technicon H*1 Autoanalyser is a dependable tool for differential white cell counting in leucopenic specimens.
- Automated analysis offers a viable and confident alternative to manual methods for these challenging samples.