No decrease in fracture risk despite 15 years of treatment evolution for multiple myeloma patients: A Danish...

Area of Science:

• Hematology
• Oncology
• Bone Metabolism

Background:

• Multiple myeloma treatment has advanced significantly.
• However, the long-term fracture risk for patients remains poorly understood.
• Bone health is a critical concern in multiple myeloma management.

Purpose of the Study:

• To investigate the temporal trends in fracture risk among multiple myeloma patients.
• To assess the impact of different treatment periods on fracture incidence.

Main Methods:

• Retrospective case-control study using Danish National Health Service data (1996-2011).
• Included 925,341 cases and matched controls, with 1334 multiple myeloma patients.
• Conditional logistic regression adjusted for comorbidities and drug use.

Main Results:

• Multiple myeloma patients exhibited a significantly higher risk of any fracture across all study periods.
• The adjusted odds ratio for any fracture ranged from 1.3 to 1.7.
• A particularly elevated risk was observed for vertebral fractures (ORadj 3.0-4.0).

Conclusions:

• Fracture risk in multiple myeloma patients has not decreased despite advancements in treatment and supportive care.
• Current treatment strategies may improve survival but do not necessarily reduce bone lesion burden.
• Ongoing research is needed to mitigate bone-related complications in multiple myeloma.