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Altered intra- and inter-network functional connectivity in patients with persistent postural-perceptual dizziness
Kangzhi Li1, Lihong Si1, Bin Cui1
1Peking University Aerospace School of Clinical Medicine, Beijing 100049, PR China.
Neuroimage. Clinical
|February 26, 2020
Summary
Persistent postural-perceptual dizziness (PPPD) involves altered brain connectivity, particularly in the precuneus, impacting sensory integration and balance. This functional vestibular disorder shows unique network changes that may explain symptoms and inform treatment strategies.
Area of Science:
- Neuroscience
- Vestibular Disorders
- Functional Neuroimaging
Background:
- Persistent postural-perceptual dizziness (PPPD) is a common functional vestibular disorder with unclear pathogenesis.
- Altered sensory integration is increasingly implicated in PPPD.
- Understanding brain network alterations is crucial for PPPD research.
Purpose of the Study:
- To investigate resting-state brain network functional connectivity (FC) changes in PPPD patients using independent component analysis (ICA) and seed-based analysis.
- To explore the role of abnormal multi-sensory integration in PPPD pathogenesis.
- To correlate FC findings with clinical measures of dizziness severity.
Main Methods:
- 12 PPPD patients and 12 healthy controls underwent resting-state functional MRI.
- Independent Component Analysis (ICA) identified intrinsic brain networks.
- Seed-based functional connectivity analysis examined FC within and between networks, focusing on the precuneus.
Main Results:
- PPPD patients exhibited decreased intra-network FC in the right precuneus (posterior default mode network).
- Altered FC was observed between the precuneus, premotor cortex, and corpus callosum.
- Increased inter-network FC was found between visual, auditory, and sensorimotor networks, correlating negatively with dizziness handicap scores.
Conclusions:
- Precuneus dysfunction in PPPD may impair environmental monitoring and motor regulation.
- Compensatory mechanisms involve enhanced interhemispheric communication via the corpus callosum.
- Visual network overactivity appears to drive sensory integration and postural control in PPPD.
