Related Experiment Video For Cervical cancer
Updated: Dec 27, 2025
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Published on: September 8, 2023
Next generation sequencing of cervical high grade dysplasia and invasive squamous cell carcinoma: A case study
Erica Vormittag-Nocito1, John V Groth1, Gayatry Mohapatra1
1Laboratory of Genomic Medicine, Department of Pathology, University of Illinois Chicago, 840 S Wood Street CSN Suite 130, Chicago 60612, USA.
Abstract:
Cervical cancer continues to be a prevalent diagnosis among gynecologic pathology despite widespread screening methods and known pathogenesis by human papilloma virus. We describe a patient who underwent next generation sequencing (NGS) of her high grade squamous dysplasia (HG-SIL) as well as the invasive component of her cervical cancer. This tumor showed an amplification of PIK3CA in the invasive carcinoma in addition to a common E542K mutation both in dysplastic and invasive carcinoma. The dysplasia also showed a novel PCNX (e1) - RAD51B (e8) fusion suggesting potentially new mechanisms of pathogenesis in cervical squamous cell carcinoma.
