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Examining the Role of Nasopharyngeal-associated Lymphoreticular Tissue NALT in Mouse Responses to Vaccines

Examining the Role of Nasopharyngeal-associated Lymphoreticular Tissue NALT in Mouse Responses to Vaccines

Published on: August 1, 2012

Nuocytes from mesenteric lymph node promote allergic responses in a mouse model.

Lin Lin¹, Xinyue Tang², Zheng Chen²

¹Huashan Hospital of Fudan University, Department of Otorhinolaryngology-Head and Neck Surgery, Shanghai, China.

Brazilian Journal of Otorhinolaryngology

|February 27, 2020

Summary

Mesenteric lymph node nuocytes promote allergic rhinitis in mice. These cells, stimulated by IL-25 and IL-33, produce key cytokines, driving allergic responses and eosinophilia.

Keywords:

Allergic rhinitis Animal models Lymph node Lymphoid cells Mice

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Last Updated: Dec 27, 2025

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Area of Science:

Immunology
Type 2 Immunity
Allergic Inflammation

Background:

Nuocytes are crucial for Type 2 immunity.
The specific role of innate lymphoid cells group 2 (ILC2s) in allergic rhinitis is not fully understood.

Purpose of the Study:

To investigate the function of nuocytes from mesenteric lymph nodes in allergic responses.
To determine the impact of nuocytes on murine models of allergic rhinitis.

Main Methods:

Nuocytes were isolated from wild-type and double-deficient mice (Il17br^-/-Il1rl1^-/-) after IL-25 and IL-33 stimulation.
Cytokine production (IL-5, IL-13) by nuocytes was assessed.
Mesenteric lymph node-derived nuocytes were adoptively transferred into a mouse model of allergic rhinitis.

Main Results:

Stimulated wild-type nuocytes produced IL-5 and IL-13.
Adoptive transfer of wild-type nuocytes exacerbated allergic rhinitis symptoms, including sneezing, nasal rubbing, and eosinophilia.
Nuocytes from double-deficient mice did not induce these allergic responses.

Conclusions:

Nuocytes from mesenteric lymph nodes play a significant role in promoting allergic rhinitis.
The IL-17BR and IL1RL1 pathways are critical for nuocyte-mediated allergic responses.