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Prolonged Hypercalcemia-Induced Psychosis.

Lauren Nagy¹, Pratheek Mangini¹, Caitlin Schroen¹

¹Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.

Case Reports in Psychiatry

|February 27, 2020

Summary

Hypercalcemia can cause psychosis, but this case shows persistent symptoms even after parathyroid adenoma removal. This highlights potential long-term neurological effects of prolonged high calcium levels.

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Area of Science:

Neuroendocrinology
Psychiatry
Calcium Metabolism

Background:

Hypercalcemia, often caused by parathyroid adenoma, is linked to neuropsychiatric dysfunction.
High calcium levels may induce neuronal damage via excitotoxicity and neurotransmitter imbalance.

Observation:

A patient with no prior psychiatric history developed prolonged delirium and psychosis post-parathyroid adenoma removal.
Symptoms persisted for at least 8 months despite medical clearance and were unresponsive to psychotropic medications.

Findings:

This case presents a rare instance of persistent psychosis following correction of hypercalcemia.
Prolonged hypercalcemia exposure may lead to enduring neuropsychiatric sequelae.

Implications:

Further research is needed to understand mechanisms of persistent psychosis after hypercalcemia.
Consideration of prolonged neuropsychiatric monitoring in patients with severe or prolonged hypercalcemia is warranted.