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Human Genetics01:28

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Updated: Dec 27, 2025

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
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Evaluating the Genetic Correlations Between Left-Handedness and Mental Disorder Using Linkage Disequilibrium Score

Bolun Cheng1, Chujun Liang1, Ping Li1

  • 1Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Collaborative Innovation Center of Endemic Diseases and Health Promotion in Silk Road Region, School of Public Health, Health Science Center, Xi'an Jiaotong University, No. 76 Yan Ta West Road, Xi'an, 710061, People's Republic of China.

Biochemical Genetics
|February 27, 2020
PubMed
Summary

This study investigated the genetic links between left-handedness and mental disorders, finding a significant genetic correlation with schizophrenia. Common genes like YWHAH, MAPT, and ANO10 were identified, offering new insights into their shared genetic basis.

Keywords:
Genetic correlationLeft-handednessSchizophreniaTranscriptome-wide association study

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Area of Science:

  • Human behavioral genetics
  • Neuroscience
  • Psychiatric genetics

Background:

  • The genetic underpinnings of human handedness remain largely unknown.
  • Understanding the genetic overlap between handedness and mental disorders is crucial for psychiatric research.

Purpose of the Study:

  • To assess genetic correlations between left-handedness and various mental disorders.
  • To identify shared genes contributing to left-handedness and schizophrenia.

Main Methods:

  • Linkage Disequilibrium Score Regression (LDSC) analysis was employed to evaluate genetic correlations.
  • Transcriptome-Wide Association Studies (TWAS), including brain RNA-seq (CBR) and brain RNA-seq splicing (CBRS), were used to identify associated genes.
  • Gene set enrichment analysis was performed on commonly identified genes.

Main Results:

  • A significant genetic correlation was found exclusively between left-handedness and schizophrenia (SCZ).
  • Several common genes, including YWHAH, MAPT, and ANO10, were associated with both left-handedness and SCZ.
  • Gene set enrichment analysis revealed biological pathways potentially linking these traits.

Conclusions:

  • This research establishes a significant genetic correlation between left-handedness and schizophrenia.
  • The identification of shared genes provides novel molecular clues for understanding the etiology of both conditions.
  • Further investigation into these shared genes may illuminate the complex genetic architecture of human behavior and psychiatric disorders.