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An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
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Molecular mechanisms underlying rheumatoid arthritis and cancer development and treatment

Susan Morand1, Hannah Staats1, Justin Fortune Creeden1

  • 1Department of Medicine, University of Toledo College of Medicine & Life Sciences, Toledo, OH 43614, USA.

Future Oncology (London, England)
|February 27, 2020
PubMed

Insights

Understanding the link between rheumatoid arthritis (RA) and cancer is crucial, especially with new immune therapies. This review explores RA

Area of Science:

  • Immunology
  • Oncology
  • Rheumatology

Background:

  • Rheumatoid arthritis (RA) affects 1% of the population, necessitating early diagnosis to prevent joint damage.
  • RA treatments, including disease-modifying antirheumatic drugs (DMARDs), modulate immune pathways, potentially impacting cancer.
  • Chronic immune dysregulation and inflammation in RA may elevate cancer development risk.

Purpose of the Study:

  • To review the mechanisms linking rheumatoid arthritis (RA) to cancer development and progression.
  • To identify potential biomarkers for cancer in RA patients.
  • To assess cancer risk and early detection strategies for individuals with RA.

Main Methods:

  • Literature review of studies on rheumatoid arthritis and cancer.
  • Analysis of immunological mechanisms connecting RA and malignancy.
  • Examination of epidemiological data on cancer incidence in RA patients.

Main Results:

  • RA is associated with an increased risk of non-Hodgkin's lymphoma and lung cancer.
  • Immune dysregulation and chronic inflammation in RA contribute to cancer development.
  • Biomarkers and early detection methods are critical for managing cancer risk in RA.

Conclusions:

  • Understanding the interplay between RA and cancer is essential for effective patient management.
  • Further research into biomarkers and early detection can improve outcomes for RA patients at risk of cancer.
  • Advances in cancer immunotherapy highlight the need to investigate autoimmunity-cancer links.
Keywords:
cancer riskcheckpoint inhibitorimmune-related adverse eventrheumatoid arthritis

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