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Echocardiographic assessment of aortic pulse wave velocity as a diagnostic and prognostic parameter for left

Haitham Galal1, Mohammed Ammar2, Magdy Ismail2

  • 1Department of Cardiology, Ain Shams University, Cairo, Egypt - haitham-w@hotmail.com.

Minerva Cardioangiologica
|February 27, 2020
PubMed

Insights

Aortic pulse wave velocity (PWV) is a sensitive marker for detecting left ventricular diastolic dysfunction (LVDD). This measurement also shows prognostic value in patients with LVDD, correlating with brain natriuretic peptide (BNP) levels.

Area of Science:

  • Cardiovascular Medicine
  • Diagnostic Imaging
  • Biomarkers

Background:

  • Aortic stiffness, measured by aortic pulse wave velocity (PWV), is linked to left ventricular diastolic dysfunction (LVDD).
  • Evaluating PWV as a diagnostic and prognostic tool for LVDD is crucial for patient management.

Purpose of the Study:

  • To assess aortic PWV as a novel diagnostic parameter for LVDD by correlating it with echocardiographic indices.
  • To determine the prognostic value of aortic PWV in LVDD patients by correlating it with brain natriuretic peptide (BNP) levels.

Main Methods:

  • A study involving 100 patients over 50 years old, divided into 80 with asymptomatic LVDD and 20 controls.
  • Measurements included echocardiography with aortic PWV assessment, and plasma BNP levels.

Main Results:

  • Aortic PWV demonstrated strong positive correlations with echocardiographic LVDD indices (E/e', TR velocity, LA volume index) and plasma BNP.
  • Significant negative correlations were found between aortic PWV and septal/lateral e'.
  • Aortic PWV showed high accuracy (89.0%) in detecting LVDD, with an optimal cutoff of 12.5 m/s.

Conclusions:

  • Echocardiographic assessment of aortic PWV is a sensitive and reliable method for detecting LVDD.
  • Aortic PWV holds promising prognostic value in patients diagnosed with LVDD.
Abstract

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