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microRNA Expression Profiling Based on Microarray Approach in Human Diabetic Retinopathy: A Systematic Review and
Hao Zhou1,2, Cheng Peng1, De-Sheng Huang1,3
1Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
DNA and Cell Biology
|February 27, 2020
Summary
MicroRNAs (miRNAs) play a role in diabetic retinopathy (DR), a leading cause of blindness. This meta-analysis identified potential DR biomarkers, including miR-320a and miR-423-5p, for future diagnostic development.
Area of Science:
- Ophthalmology
- Genetics
- Endocrinology
Background:
- Diabetic retinopathy (DR) is a major microvascular complication of diabetes mellitus (DM), leading to irreversible vision loss.
- MicroRNAs (miRNAs) are increasingly implicated in the pathogenesis of DR.
Purpose of the Study:
- To conduct a meta-analysis of published miRNA expression profiling studies in DR patients versus controls.
- To identify consistently dysregulated miRNAs that may serve as potential biomarkers for DR.
Main Methods:
- Systematic literature search for miRNA expression profiling studies comparing DR patients and control groups.
- Meta-analysis of eight selected publications, analyzing 93 differentially expressed miRNAs.
- Stratification of results by biological sample type (serum, vitreous humor).
Main Results:
- Six miRNAs showed consistent differential expression across studies.
- miR-320a was consistently upregulated in serum samples.
- miR-423-5p was consistently upregulated in vitreous humor samples.
- miR-27b was consistently downregulated in serum samples.
Conclusions:
- The identified miRNAs (miR-320a, miR-423-5p, miR-27b) may serve as potential biomarkers for DR.
- Further research into miRNA mechanisms and external validation is needed for developing diagnostic markers.
- These findings could aid in preventing or reversing vision loss associated with DR.
