Relationship between serum calcium and creatinine in hematopoietic stem cell transplantation patients treated with

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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

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Ryosuke Ota, Atsushi Hirata, Keisuke Noto

    International Journal of Clinical Pharmacology and Therapeutics
    |February 27, 2020
    PubMed

    Insights

    Serum creatinine and calcium (Ca) levels show an inverse relationship in hematopoietic stem cell transplantation (HSCT) patients with foscarnet-induced renal dysfunction. Monitoring Ca may help detect early kidney problems.

    Area of Science:

    • Nephrology
    • Hematology
    • Pharmacology

    Background:

    • Foscarnet is used in hematopoietic stem cell transplantation (HSCT) but can cause kidney damage.
    • The relationship between serum creatinine and calcium (Ca) in HSCT patients receiving foscarnet is not fully understood.

    Purpose of the Study:

    • To investigate the relationship between serum creatinine and Ca levels in HSCT patients treated with foscarnet.
    • To determine if Ca levels can predict foscarnet-induced renal dysfunction.

    Main Methods:

    • Retrospective study of 42 HSCT patients treated with foscarnet.
    • Renal dysfunction classified using Kidney Disease: Improving Global Outcomes (KDIGO) criteria.
    • Statistical analysis of serum creatinine and Ca levels.

    Main Results:

    • A significant inverse relationship was found between serum creatinine and Ca levels (r = -0.372, p < 0.0001).
    • This inverse relationship was significant in the renal dysfunction group (r = -0.531, p < 0.0001) but not in the non-renal dysfunction group.
    • An optimal cutoff for minimum Ca level was 8.1 mg/dL.

    Conclusions:

    • Serum creatinine and Ca levels have a significant inverse relationship in HSCT patients with foscarnet-induced renal dysfunction.
    • A Ca level below 8.1 mg/dL may indicate foscarnet-induced renal dysfunction.
    • Monitoring Ca levels can aid in early detection of renal dysfunction in foscarnet-treated patients.
    Abstract

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