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On Epigenetic Plasticity and Genome Topology
Charalampos Lazaris1, Iannis Aifantis1, Aristotelis Tsirigos2
1Department of Pathology, New York University School of Medicine, New York, NY 10016, USA; Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY 10016, USA.
Trends in Cancer
|February 27, 2020
Summary
Genetic lesions can alter genome topology and gene activation. Epigenetic plasticity, including DNA methylation and long noncoding RNAs (lncRNAs), plays a crucial role in maintaining genome integrity and function.
Area of Science:
- Genomics
- Epigenetics
- Molecular Biology
Background:
- Genetic lesions are increasingly linked to altered genome topology and aberrant gene activation.
- The precise contribution of epigenetic plasticity to these processes remains largely undetermined.
- Emerging evidence suggests roles for DNA methylation, transcriptional elongation, long noncoding RNAs (lncRNAs), and CCCTC-binding factor (CTCF)-RNA interactions.
Purpose of the Study:
- To systematically investigate the role of epigenetic plasticity in maintaining genome integrity and function.
- To elucidate the mechanisms by which epigenetic factors influence genome topology and gene expression.
Main Methods:
- Systematic analysis of epigenetic modifications.
- Genome-wide studies of DNA methylation patterns.
- Investigation of lncRNA expression and function.
- Analysis of CTCF-RNA interactions and their impact on genome topology.
Main Results:
- (Results will be detailed here upon study completion)
Conclusions:
- Epigenetic plasticity is a critical factor in genome integrity and function.
- Understanding these mechanisms is essential for deciphering the impact of genetic lesions on cellular processes.
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