Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Tumor Progression02:07

Tumor Progression

7.1K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.1K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

83.1K
Overview
83.1K
Cancer Vaccines01:30

Cancer Vaccines

880
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
880
Abnormal Proliferation02:23

Abnormal Proliferation

5.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
Immunological Memory01:23

Immunological Memory

14.7K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
14.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Application of a translational research platform to unveil efficacy signals and mechanisms of resistance of FGFR inhibitors in multiple FGFR-altered solid tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

The impact of body mass index on early readmission and reoperation following endoscopic vs. open/microsurgical lumbar surgery: A nationwide analysis.

Clinical neurology and neurosurgery·2026
Same author

Phase I/Ib study evaluating safety, efficacy, pharmacokinetics and pharmacodynamics of NIZ985 monotherapy and in combination with an anti-PD-1 agent in patients with advanced solid tumors or lymphoma.

European journal of cancer (Oxford, England : 1990)·2026
Same author

A prospective, open-label feasibility study protocol of home-based transcranial direct current stimulation for major depressive disorder in elective lumbar spine surgery candidates.

Frontiers in human neuroscience·2026
Same author

Response of Spinal Cord Blood Flow to Hypotensive and Adrenergic Challenges: Doppler Ultrasound of the Porcine Sulcal Artery.

Neurosurgery·2026
Same author

Inequities in enrollment across clinical trial phases and the need for a Spanish perspective.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2026

Related Experiment Video

Updated: Dec 27, 2025

Ex vivo Expansion of Tumor-reactive T Cells by Means of Bryostatin 1/Ionomycin and the Common Gamma Chain Cytokines Formulation
07:20

Ex vivo Expansion of Tumor-reactive T Cells by Means of Bryostatin 1/Ionomycin and the Common Gamma Chain Cytokines Formulation

Published on: January 14, 2011

15.1K

Hyperprogression and Immunotherapy: Fact, Fiction, or Alternative Fact?

Jacob J Adashek1, Ishwaria M Subbiah2, Ignacio Matos3

  • 1University of South Florida, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.

Trends in Cancer
|February 27, 2020
PubMed
Summary

Immunotherapy (IO) can paradoxically accelerate cancer progression in some patients, a phenomenon known as hyperprogressive disease (HPD). Further research is needed to understand HPD

Keywords:
cancer clinical trialshyperprogressive diseaseimmune checkpoint inhibitorsimmunotherapy

More Related Videos

Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype
08:49

Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype

Published on: March 18, 2020

11.5K
Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

3.8K

Related Experiment Videos

Last Updated: Dec 27, 2025

Ex vivo Expansion of Tumor-reactive T Cells by Means of Bryostatin 1/Ionomycin and the Common Gamma Chain Cytokines Formulation
07:20

Ex vivo Expansion of Tumor-reactive T Cells by Means of Bryostatin 1/Ionomycin and the Common Gamma Chain Cytokines Formulation

Published on: January 14, 2011

15.1K
Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype
08:49

Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype

Published on: March 18, 2020

11.5K
Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

3.8K

Area of Science:

  • Oncology
  • Immunology

Background:

  • Immunotherapy (IO) has revolutionized cancer treatment.
  • A subset of patients paradoxically experiences accelerated disease progression, termed hyperprogressive disease (HPD).
  • HPD incidence ranges from 4% to 29% in reported studies.

Purpose of the Study:

  • To summarize the current understanding of hyperprogressive disease (HPD) in cancer patients treated with immunotherapy.
  • To highlight the need for prospective studies to elucidate HPD mechanisms and management.

Main Methods:

  • Review of emerging retrospective data on HPD.
  • Discussion of proposed biological mechanisms, including Fc region involvement and genetic amplifications (EGFR, MDM2/MDM4).

Main Results:

  • HPD represents a significant challenge, with varying reported incidence rates.
  • Potential biological underpinnings of HPD are under investigation.
  • The nature of HPD is debated, with some suggesting it reflects natural disease history.

Conclusions:

  • Prospective studies are essential to confirm HPD biology.
  • Predictive biomarkers for HPD susceptibility are needed.
  • Optimal therapeutic strategies following HPD require determination.