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Related Experiment Video

Updated: Dec 27, 2025

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

Phase-Specific Microstimulation Differentially Modulates Beta Oscillations and Affects Behavior.

Oren Peles¹, Uri Werner-Reiss¹, Hagai Bergman¹

¹Department of Medical Neurobiology, Institute of Medical Research-Israel Canada, The Hebrew University-Hadassah Medical School, Jerusalem 9112102, Israel; Edmond and Lily Safra Centre for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel.

|February 27, 2020

Summary

This summary is machine-generated.

Brain-machine interfaces enhance Beta-band oscillations in monkeys, revealing their role in sensorimotor control. Phase-specific microstimulation impacts performance, offering insights for treating brain disorders.

Keywords:

Beta oscillations brain-machine interface local field potential microsimulation motor cortex non-human primates operant conditioning

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Last Updated: Dec 27, 2025

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

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Published on: June 29, 2018

Automatic Detection of Highly Organized Theta Oscillations in the Murine EEG

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Published on: March 10, 2017

Brain State-dependent Brain Stimulation with Real-time Electroencephalography-Triggered Transcranial Magnetic Stimulation

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Published on: August 20, 2019

Area of Science:

Neuroscience
Systems Neuroscience
Computational Neuroscience

Background:

Beta-band oscillations (20-30 Hz) are implicated in sensorimotor functions.
Understanding their precise role requires advanced experimental techniques.

Purpose of the Study:

To investigate the functional role of Beta-band oscillations in sensorimotor behavior.
To explore the effects of volitionally controlling and perturbing these oscillations.

Main Methods:

Developed a hybrid platform combining neural operant conditioning and phase-specific intracortical microstimulation (ICMS).
Trained monkeys with motor cortex implants to enhance local field potential (LFP) Beta-band activity via a brain-machine interface (BMI).
Applied phase-specific ICMS to modulate oscillation power and phase.

Main Results:

BMI training significantly increased Beta-band oscillations in LFP and single-unit activity.
Pre-movement Beta power was negatively correlated with task performance.
Phase-specific ICMS altered oscillation states and induced phase-dependent effects on reaction times and success rates.

Conclusions:

Beta-band oscillations are dynamically modulated during sensorimotor tasks and influence performance.
Phase-specific ICMS can manipulate neural network states and behavior.
Findings advance understanding of cortical oscillations and inform development of clinical interventions for neurological disorders.